AB231263

Anti-ZBTB38抗体

Name: ZBTB38抗体 (ab231263)| Abcam中文官网
Brand: Abcam Limited
SKU: AB231263
Price: 4748 CNY
Availability: InStock

Anti-ZBTB38 antibody

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(1 Publication)

Rabbit Polyclonal ZBTB38 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Zinc finger and BTB domain-containing protein 38 conjugated to Keyhole Limpet Haemocyanin.

查看别名

Zinc finger and BTB domain-containing protein 38, ZBTB38

1 Images

Supplier Data

Western blot - Anti-ZBTB38 antibody (AB231263)

Dilution buffer : TBS-Tween containing 5% skimmed milk.

All lanes:

Western blot - Anti-ZBTB38 antibody (ab231263) at 1/1000 dilution

All lanes:

Nuclear extracts of HeLa (human epithelial cell line from cervix adenocarcinoma) cells at 40 µg

Predicted band size: 134 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human Zinc finger and BTB domain-containing protein 38 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8NAP3

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯度

Whole antiserum

存储溶液

Preservative: 0.05% Sodium azide

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The ZBTB38 protein also known as CIBZ (CTCFL interacting BTB zinc finger protein) functions as a transcriptional regulator with a molecular mass of approximately 149 kDa. It contains zinc finger motifs that bind to DNA sequences to modulate gene expression. ZBTB38 mostly localizes in the nucleus of cells and shows expression in human tissues such as brain heart and skeletal muscle. The presence in these tissues indicates an important role in fundamental cellular processes.

Biological function summary

The regulatory role of ZBTB38 impacts cell cycle control and differentiation. It participates in transcriptional repression or activation depending on the interacting partners. Known to form part of multisubunit complexes ZBTB38 can engage in molecular interactions that influence chromatin remodeling. Through these configurations it affects the transcriptional regulation of target genes influencing cellular functions and development pathways.

Pathways

ZBTB38 is involved in the regulation of the Wnt and MAPK signaling pathways. These pathways play a significant role in cell proliferation differentiation and survival. ZBTB38 directly interacts with proteins such as CTCF (CCCTC-binding factor) and CTCFL (CTCF-like) in these pathways influencing various cellular responses. The precise modulation of these pathways by ZBTB38 contributes to maintaining cellular homeostasis and dynamics.

Disruptions in ZBTB38 function are linked to certain cancers and developmental disorders. Abnormal expression or mutations in ZBTB38 are associated with an increased risk of neuroblastoma where it interacts with MYC a known oncogene. Additionally changes in ZBTB38 are connected with developmental syndromes possibly through its interactions with CTCF impacting gene expression profiles relevant to these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed : 16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed : 24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).

See full target information Zinc finger and BTB domain-containing protein 38

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 13: PubMed37238701

2023

Lipoxin A4 (LXA4) Reduces Alkali-Induced Corneal Inflammation and Neovascularization and Upregulates a Repair Transcriptome.

Applications

Unspecified application

Species

Unspecified reactive species

Jiucheng He,Thang L Pham,Azucena H Kakazu,Abhilash Ponnath,Khanh V Do,Haydee E P Bazan

View all publications

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Anti-ZBTB38抗体

Anti-ZBTB38 antibody

Western blot - Anti-ZBTB38 antibody (AB231263)