Rabbit Polyclonal XPA antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human XPA.
查看别名
XPAC, XPA, DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XPA antibody (AB180618)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung cancer tissue labelling XPA with ab180618 at 1/200. Magnification : 200x.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-XPA antibody (AB180618)
Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cell using ab180618 Green : GFP-RNF168 fusion protein expression for DNA damage marker. Blue : DAPI for nuclear staining. RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XPA antibody (AB180618)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat brain tissue labelling XPA with ab180618 at 1/200. Magnification : 200x.
- WB
Supplier Data
Western blot - Anti-XPA antibody (AB180618)
All lanes:
Western blot - Anti-XPA antibody (ab180618) at 1/500 dilution
All lanes:
HEK293 cell line extract
Predicted band size: 31 kDa
false
反应性数据
性能和储存信息
形式
纯化工艺
存储溶液
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The protein is essential for maintaining genomic stability by facilitating the repair of DNA lesions. XPA operates within a multiprotein complex that includes the proteins ERCC1 and XPF. The complex identifies a wide range of structural abnormalities in DNA such as UV-induced photoproducts and chemically induced adducts. Without XPA the NER system's efficiency decreases leaving cells vulnerable to genotoxic stresses causing mutations and damage accumulation.
Pathways
XPA plays a role in the nucleotide excision repair and the base excision repair pathways. These pathways work jointly to ensure the removal of damaged DNA sections and accurate DNA synthesis. Within the NER pathway XPA interacts with proteins like RPA (Replication Protein A) and TFIIH (Transcription Factor IIH) to mediate the excision of damaged oligonucleotides. Its activity is critical for preserving the integrity of the genetic code especially in response to DNA damage caused by external agents like UV radiation.
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靶点信息
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
Infectious agents and cancer 17:52 PubMed36195933
2022
Applications
Unspecified application
Species
Unspecified reactive species
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