AB169597

Anti-WDR9/BRWD1抗体

Name: WDR9/BRWD1抗体 (ab169597)| Abcam中文官网
Brand: Abcam Limited
SKU: AB169597
Price: 4560 CNY
Availability: InStock

Anti-WDR9/BRWD1 antibody

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(2 Publications)

Mouse Polyclonal WDR9/BRWD1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BRWD1.

查看别名

C21orf107, WDR9, BRWD1, Bromodomain and WD repeat-containing protein 1, WD repeat-containing protein 9

1 Images

Unknown

Western blot - Anti-WDR9/BRWD1 antibody (AB169597)

All lanes:

Western blot - Anti-WDR9/BRWD1 antibody (ab169597) at 1 µg/mL

Lane 1:

WDR9/BRWD1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 263 kDa

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关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human BRWD1.

Q9NSI6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The WDR9/BRWD1 protein is also known by its alternate name BRWD1 and has a molecular mass of approximately 250 kDa. This protein shows expression in various tissues with higher levels observed in testis and certain brain regions. WDR9/BRWD1 is a member of the WD-repeat protein family and contains two bromodomains. Mechanically it plays a role in mediating protein-protein interactions aiding in chromatin organization and gene regulation.

Biological function summary

WDR9/BRWD1 functions in regulating transcriptional processes and is often part of nuclear chromatin complexes. It participates in gene expression important for spermatogenesis and neuronal differentiation. This protein interacts with other chromatin-modifying proteins contributing to the alteration of chromatin states and affecting cellular programs.

Pathways

Different regulatory and developmental processes involve WDR9/BRWD1. The protein plays roles within chromatin remodeling pathways. It engages with pathways such as histone modification and transcriptional regulation working alongside proteins like histones and other transcription factors which helps coordinate the accessibility of transcriptional machinery to DNA.

Abnormal WDR9/BRWD1 expression or mutations have connections to neurological and reproductive conditions. Studies link its dysregulation to intellectual disabilities and fertility issues. Its association with chromatin-modifying proteins implicates it in diseases where gene expression regulation plays a role such as certain cognitive disorders.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

See full target information BRWD1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Human genetics 140:761-773 PubMed33389130

2021

Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Guo,Chao-Feng Tu,Dan-Hui Yang,Shui-Zi Ding,Cheng Lei,Rong-Chun Wang,Lv Liu,Xi Kang,Xiao-Qing Shen,Yi-Feng Yang,Zhi-Ping Tan,Yue-Qiu Tan,Hong Luo

International journal of clinical and experimental pathology 11:2488-2496 PubMed31938361

2018

Effects of melatonin on diabetic nephropathy rats via Wnt/β-catenin signaling pathway and TGF-β-Smad signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Weichao Wang,Jie Zhang,Xiaohang Wang,Hong Wang,Qiaohua Ren,Yukun Li

View all publications

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Anti-WDR9/BRWD1抗体

Anti-WDR9/BRWD1 antibody

Western blot - Anti-WDR9/BRWD1 antibody (AB169597)