AB203345

Anti-WDR26 抗体

Name: WDR26抗体 (ab203345)| Abcam中文官网
Brand: Abcam Limited
SKU: AB203345
Price: 4606 CNY
Availability: InStock
Rating: 1 (1 reviews)

Anti-WDR26 antibody

(1 Review)

(2 Publications)

Rabbit Polyclonal WDR26 antibody. Suitable for IHC-P and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human WDR26 aa 250-350 conjugated to Keyhole Limpet Haemocyanin.

查看别名

CDW2, MIP2, PRO0852, WDR26, WD repeat-containing protein 26, CUL4- and DDB1-associated WDR protein 2, Myocardial ischemic preconditioning up-regulated protein 2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR26 antibody (AB203345)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR26 antibody (AB203345)

Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human laryngocarcinoma section labeling WDR26 with ab203345 at at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR26 antibody (AB203345)

Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded rat heart section labeling WDR26 with ab203345 at at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat, Human

应用

IHC-P

applications

免疫原

Synthetic Peptide within Human WDR26 aa 250-350 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9H7D7

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe please use a dilution of 1/50 - 1/200.</p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>When using a fluorescent probe please use a dilution of 1/50 - 1/200.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

WDR26 also known as WD repeat domain 26 is part of the WD repeat protein family which is important in protein-protein interactions. It weighs roughly 109 kDa. WDR26 expresses in various tissues with significant levels observed in the brain and testis. The protein itself has a molecular architecture enriched with WD repeats which facilitates its involvement in cellular processes by mediating complex formation and signal transduction.

Biological function summary

In the cellular environment WDR26 engages in regulating intracellular signaling pathways. It is a component of the STRIPAK complex which includes several proteins playing roles in synaptic and cellular signaling. The involvement of WDR26 in the STRIPAK complex as a scaffold aids in the correct assembly and localization of the complex impacting cellular processes such as apoptosis and proliferation.

Pathways

WDR26 integrates into key signaling pathways like the MAPK signaling pathway. It interacts with other proteins such as STRN3 and MOB3 to modulate signals that affect gene expression growth and cell differentiation. The MAPK pathway in particular facilitates responses to growth factors stress signals and mitogens illustrating the protein's versatility in signal transduction.

Defects or dysregulation of WDR26 relate to intellectual disabilities and certain neurodevelopmental disorders. Research indicates that changes in WDR26 expression can disturb normal brain development and function often connecting with other proteins like MEK1 which also participates in neurodevelopment. These connections link WDR26 closely to neurological functions and highlight its potential as a target for therapeutic interventions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

G-beta-like protein involved in cell signal transduction (PubMed : 15378603, PubMed : 19446606, PubMed : 22065575, PubMed : 23625927, PubMed : 26895380, PubMed : 27098453). Acts as a negative regulator in MAPK signaling pathway (PubMed : 15378603). Functions as a scaffolding protein to promote G beta : gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed : 22065575, PubMed : 23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed : 29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed : 27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed : 26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed : 19446606). Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).

See full target information WDR26

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

eLife 10: PubMed34029184

2021

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin-induced corpus luteum regression.

Applications

Unspecified application

Species

Unspecified reactive species

Dianrong Li,Jie Chen,Jia Guo,Lin Li,Gaihong Cai,She Chen,Jia Huang,Hui Yang,Yinhua Zhuang,Fengchao Wang,Xiaodong Wang

Nature communications 11:5156 PubMed33056990

2020

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Napoli,Xiaobo Li,Hayley D Ackerman,Avani A Deshpande,Ivan Barannikov,Marlese A Pisegna,Isabelle Bedrosian,Jürgen Mitsch,Philip Quinlan,Alastair Thompson,Kimal Rajapakshe,Cristian Coarfa,Preethi H Gunaratne,Douglas C Marchion,Anthony M Magliocco,Kenneth Y Tsai,Elsa R Flores

View all publications

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Anti-WDR26 抗体

Anti-WDR26 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR26 antibody (AB203345)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WDR26 antibody (AB203345)