AB176261

Anti-WDR18抗体

Name: WDR18抗体 (ab176261)| Abcam中文官网
Brand: Abcam Limited
SKU: AB176261
Price: 4606 CNY
Availability: InStock

Anti-WDR18 antibody

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(1 Publication)

Rabbit Polyclonal WDR18 antibody. Suitable for WB and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human WDR18.

查看别名

WD repeat-containing protein 18, WDR18

1 Images

Supplier Data

Western blot - Anti-WDR18 antibody (AB176261)

Lane 1:

Western blot - Anti-WDR18 antibody (ab176261) at 0.5 µg/mL

Lane 2:

Western blot - Anti-WDR18 antibody (ab176261) at 1 µg/mL

All lanes:

Rat lung tissue lysate at 15 µg

Predicted band size: 47 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

applications

免疫原

Synthetic Peptide within Human WDR18. The exact immunogen used to generate this antibody is proprietary information.

Q9BV38

特异性

ab176261 is predicted to not cross-react with other WDR family members.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

WDR18 also known as WD repeat domain 18 is a protein that plays a role in cellular assembly processes. It has a mass of approximately 58 kDa and is found in several tissues including the brain and liver. WDR18 interacts with proteins containing WD repeats and functions as a scaffold for multiprotein complex assembly. This scaffolding role is essential in managing protein interactions necessary for cellular structure and movement.

Biological function summary

WDR18 functions within ribonucleoprotein complexes that are important for ribosome biogenesis. It acts in coordination with proteins like NOP58 and NCL within the nucleolus an important site for ribosome synthesis. These complexes support the correct processing of ribosomal RNA which is critical for cell growth and proliferation. WDR18 contributes to maintaining cellular protein synthesis ensuring effective cellular division and function.

Pathways

WDR18 participates in ribosome biogenesis and assembly pathways. It works alongside proteins within the mTOR signaling pathway which modulates cell growth and metabolism. In these pathways WDR18 supports interactions with other key proteins such as S6K1 and eIF4E ensuring accurate translation and cellular homeostasis. This integration into essential cellular pathways underlies its importance in managing cell growth and protein production.

WDR18 is associated with certain cancers and developmental disorders. In particular abnormalities in WDR18 expression can correlate with tumorigenesis in cancers like liver cancer. Connections with proteins such as MYC highlight its role in cancerous cell proliferation. Also mutations in WDR18 have been related to developmental issues affecting neural and physical development demonstrating its involvement in maintaining healthy cellular and organismal development.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed : 22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed : 21326211). May play a role during development (By similarity).

See full target information WDR18

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nutrition & metabolism 19:17 PubMed35248109

2022

The combination of endurance exercise and SGTC (Salvia-Ginseng-Trigonella-Cinnamon) ameliorate mitochondrial markers' overexpression with sufficient ATP production in the skeletal muscle of mice fed AGEs-rich high-fat diet.

Applications

Unspecified application

Species

Unspecified reactive species

Maryam Haghparast Azad,Iman Niktab,Shaghayegh Dastjerdi,Navid Abedpoor,Golbarg Rahimi,Zahra Safaeinejad,Maryam Peymani,Farzad Seyed Forootan,Majid Asadi-Shekaari,Mohammad Hossein Nasr Esfahani,Kamran Ghaedi

View all publications

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Anti-WDR18抗体

Anti-WDR18 antibody

Western blot - Anti-WDR18 antibody (AB176261)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性