AB242072

violetFluor™ 450 Anti-CD161抗体[HP-3G10]

Name: violetFluor™ 450 Anti-CD161抗体[HP-3G10] (ab242072)| Abcam中文官网
Brand: Abcam Limited
SKU: AB242072
Price: 1732 CNY
Availability: InStock

violetFluor™ 450 Anti-CD161 antibody [HP-3G10]

Be the first to review this product! Submit a review

(1 Publication)

Mouse Monoclonal KLRB1 antibody - conjugated to violetFluor™ 450. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication.

查看别名

CD161, CLEC5B, NKRP1A, KLRB1, Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, Natural killer cell surface protein P1A, NKR-P1A

1 Images

Flow Cytometry - violetFluor™ 450 Anti-CD161 antibody [HP-3G10] (AB242072)

Flow Cyt

Supplier Data

Flow Cytometry - violetFluor™ 450 Anti-CD161 antibody [HP-3G10] (AB242072)

Flow cytometric analysis of human peripheral blood lymphocytes labeling CD161 using ab242072 at 0.5 μg/test (right panel) compared to an isotype control (left panel).

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

HP-3G10

亚型

IgG1

轻链类型

kappa

偶联物

violetFluor™ 450

激发波长/发射波长

Ex: 405nm, Em: 450nm

不含载体蛋白

反应种属

Human

应用

Flow Cyt

applications

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p>The antibody has been diluted for use at 5 μl per test, defned as the amount of antibody that will stain a cell sample in a final volume of approximately 100 μl. The number of cells within a sample should be determined empirically, but typically ranges between 1 x 10e5 to 1 x 10e8 cells.</p>" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification

纯化说明

ab242072 was purified from tissue culture supernatant via affinity chromatography

存储溶液

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.12% Sodium dihydrogen phosphate, 0.1% Gelatin

运输条件

Blue Ice

储存信息

Store in the dark

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD161 also known as NKRP1A or KLRB1 is a type II transmembrane protein expressed primarily on natural killer (NK) cells and subsets of T cells. Weighing approximately 30-40 kDa CD161 functions as a C-type lectin receptor involved in the immune response. Its expression can be detected in various tissues including the liver and spleen. Researchers utilize tools such as mouse CD161 PE as well as CD161 APC antibodies for study of its cell surface expression and role in immune modulation.

Biological function summary

CD161 plays a role in immune system regulation by mediating NK cell and T cell activity. It does not operate as part of a complex but interacts with other cellular receptors to modulate immune responses. For example it serves as an inhibitory receptor often through engagement with its ligand LLT1 to temper immune responses and prevent overactivation. This balance is key to maintaining immune homeostasis and facilitates pathogen clearance while avoiding excessive tissue damage.

Pathways

CD161 is involved in the immune checkpoint pathways and is linked to inflammatory response signaling. These pathways play an important role in the immune system's ability to discern self from non-self determining the intensity and character of the body's defense mechanisms. Other proteins such as CTLA-4 and PD-1 also function within these pathways contributing to the regulation of immune cell activity and preventing autoimmunity.

CD161 is associated with inflammatory diseases and cancer. Its involvement in immune checkpoints implicates it in conditions such as autoimmune diseases where it may fail to properly regulate immune activity including multiple sclerosis. In cancer CD161 expression on T cells has been examined in the context of its inhibitory role potentially modulating the immune system's ability to target tumor cells effectively. In these scenarios its interaction with LLT1 and other immune checkpoint proteins influences the disease course and therapeutic outcomes.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

See full target information KLRB1

style

left-column