Anti-Versican抗体(ab19345)
Key features and details
- Rabbit polyclonal to Versican
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术，可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Versican抗体
参阅全部 Versican 一抗 -
描述
兔多克隆抗体to Versican -
宿主
Rabbit -
特异性
This antibody can be used to detect versican V1 (ADAMTS-1/4 site). This product is against the neoepitope of versican generated by cleavage of the versican core protein by ATAMTS 1/4. -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rat
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免疫原
Synthetic peptide: CGG- DPEAAE, corresponding to amino acids 436-441 of Human Versican (Peptide available as ab39784.)
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab19345于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (2) |
Use a concentration of 1 µg/ml. Detects a band of approximately 70 kDa.Can be blocked with Human Versican peptide (ab39784).
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| 说明 |
|---|
|
WB
Use a concentration of 1 µg/ml. Detects a band of approximately 70 kDa.Can be blocked with Human Versican peptide (ab39784). |
靶标
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功能
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. -
组织特异性
Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas. -
疾病相关
Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. -
序列相似性
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 2 EGF-like domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 2 Link domains.
Contains 1 Sushi (CCP/SCR) domain. -
发展阶段
Disappears after the cartilage development. -
翻译后修饰
Phosphorylation sites are present in the extracelllular medium. -
细胞定位
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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数据库链接
- Entrez Gene: 1462 Human
- Entrez Gene: 114122 Rat
- Omim: 118661 Human
- SwissProt: P13611 Human
- SwissProt: Q9ERB4 Rat
- Unigene: 643801 Human
- Unigene: 715773 Human
- Unigene: 35666 Rat
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别名
- Chondroitin sulfate proteoglycan 2 antibody
- Chondroitin sulfate proteoglycan core protein 2 antibody
- Chondroitin sulfate proteoglycan core protein, cartilage antibody
see all
图片
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Western blot - Anti-Versican antibody (ab19345)Anti-Versican antibody (ab19345) at 1 µg/ml + Lysates prepared from human aorta
数据表及文件
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SDS download
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Datasheet download
文献 (74)
ab19345 被引用在 74 文献中.
- Spella M et al. Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ. Cancers (Basel) 15:N/A (2023). PubMed: 36980752
- Watkins B et al. Degeneration of muscle spindles in a murine model of Pompe disease. Sci Rep 13:6555 (2023). PubMed: 37085544
- Sánchez-Porras D et al. Histochemical and Immunohistochemical Methods for the Identification of Proteoglycans. Methods Mol Biol 2566:85-98 (2023). PubMed: 36152244
- Bornstein B et al. Molecular characterization of the intact mouse muscle spindle using a multi-omics approach. Elife 12:N/A (2023). PubMed: 36744866
- James S et al. Short-Term Exposure to Ciprofloxacin Reduces Proteoglycan Loss in Tendon Explants. Genes (Basel) 13:N/A (2022). PubMed: 36553476