Anti-VEGF Receptor 3抗体[RM0003-5F63] (ab51874)
![Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (ab51874)](https://www.abcam.cn/ps/products/51/ab51874/Images/ab51874-63945-anti-vegf-receptor-3-antibody-rm0003-5f63-immunohistochemistry.jpg "Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (ab51874)")
Key features and details
- Rat monoclonal [RM0003-5F63] to VEGF Receptor 3
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG2
概述
-
产品名称
Anti-VEGF Receptor 3抗体[RM0003-5F63]
参阅全部 VEGF Receptor 3 一抗 -
描述
大鼠单克隆抗体[RM0003-5F63] to VEGF Receptor 3 -
宿主
Rat -
特异性
No cross reactivity to mouse VEGFR1 and VEGFR2. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant full length protein corresponding to Mouse VEGF Receptor 3 (extracellular).
Database link: P35917 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
RM0003-5F63 -
同种型
IgG2 -
研究领域
相关产品
-
Compatible Secondaries
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab51874于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use at an assay dependent concentration.
Use at 1/100-1/500 dilution |
| 说明 |
|---|
|
IHC-P
Use at an assay dependent concentration. Use at 1/100-1/500 dilution |
靶标
-
功能
Receptor for VEGFC. Has a tyrosine-protein kinase activity. -
组织特异性
Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain. -
疾病相关
Defects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.
Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
细胞定位
Membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 14257 Mouse
- SwissProt: P35917 Mouse
- Unigene: 3291 Mouse
-
别名
- EC 2.7.10.1 antibody
- flt 4 antibody
- FLT-4 antibody
see all
图片
-
Immunohistochemistry paraffin embedded sections - Anti-VEGF Receptor 3 antibody [RM0003-5F63] (ab51874)
ab51874 at 1/500 dilution, staining VEGF Receptor 3 in mouse heart tissue section by Immunohistochemistry (paraffin-embedded sections).
数据表及文件
-
Datasheet download
文献 (5)
ab51874 被引用在 5 文献中.
- Follain G et al. Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells. Sci Rep 11:13144 (2021). PubMed: 34162963
- Peng J et al. Sema4C modulates the migration of primary tumor-associated lymphatic endothelial cells via an ERK-mediated pathway. Exp Ther Med 22:1102 (2021). PubMed: 34504556
- Henri O et al. Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction. Circulation 133:1484-97; discussion 1497 (2016). PubMed: 26933083
- Sun Z et al. Downregulation of long non-coding RNA ANRIL suppresses lymphangiogenesis and lymphatic metastasis in colorectal cancer. Oncotarget 7:47536-47555 (2016). PubMed: 27286457
- Park JA et al. Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression. PLoS Genet 11:e1005324 (2015). PubMed: 26147525
