Anti-VE-PTP抗体[122.2] (ab31654)
Key features and details
- Mouse monoclonal [122.2] to VE-PTP
- Suitable for: ICC, IP, ICC/IF, WB
- Reacts with: Rat
- Isotype: IgM
概述
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产品名称
Anti-VE-PTP抗体[122.2]
参阅全部 VE-PTP 一抗 -
描述
小鼠单克隆抗体[122.2] to VE-PTP -
宿主
Mouse -
特异性
This antibody is specific for Receptor Tyrosine Phosphatase Beta (phosphacan). -
经测试应用
适用于: ICC, IP, ICC/IF, WBmore details -
种属反应性
与反应: Rat -
免疫原
Tissue, cells or virus corresponding to Rat VE-PTP. (Embryonic rat brain proteoglycans).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
Constituent: PBS -
Concentration information loading... -
纯化说明
Concentrated antibody. This antibody was grown in protein free medium, then concentrated snd dialysed against PBS. -
克隆
单克隆 -
克隆编号
122.2 -
同种型
IgM -
研究领域
相关产品
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Compatible Secondaries
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab31654于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| ICC/IF |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
ICC
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. |
靶标
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功能
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. -
序列相似性
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Contains 17 fibronectin type-III domains.
Contains 1 tyrosine-protein phosphatase domain. -
细胞定位
Membrane. - Information by UniProt
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别名
- HPTP BETA antibody
- HPTPB antibody
- Phosphacan receptor type B antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (1)
ab31654 被引用在 1 文献中.
- Ou M et al. HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA-520d-3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm. ESC Heart Fail 9:2955-2966 (2022). PubMed: 35730141
