Anti-VDAC2抗体(ab37985)
Key features and details
- Goat polyclonal to VDAC2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-VDAC2抗体
参阅全部 VDAC2 一抗 -
描述
山羊多克隆抗体to VDAC2 -
宿主
Goat -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Rabbit, Cow, Dog, Pig -
免疫原
Synthetic peptide corresponding to Human VDAC2 aa 250 to the C-terminus (C terminal).
Database link: P45880 -
阳性对照
- WB: Human cerebellum cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab37985于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB | (7) |
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa).
1 hour primary incubation is recommended for this product. |
说明 |
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WB
Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa). 1 hour primary incubation is recommended for this product. |
靶标
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功能
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. -
组织特异性
Expressed in all tissues examined. -
序列相似性
Belongs to the eukaryotic mitochondrial porin family. -
结构域
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. -
细胞定位
Mitochondrion outer membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 282120 Cow
- Entrez Gene: 479255 Dog
- Entrez Gene: 7417 Human
- Entrez Gene: 397659 Pig
- Omim: 193245 Human
- SwissProt: P45880 Human
- SwissProt: Q9MZ15 Pig
- Unigene: 355927 Human
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别名
- B-36 vdac antibody
- FLJ23841 antibody
- hVDAC2 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (22)
ab37985 被引用在 22 文献中.
- Battaglia AM et al. Iron affects the sphere-forming ability of ovarian cancer cells in non-adherent culture conditions. Front Cell Dev Biol 11:1272667 (2023). PubMed: 38033861
- Battaglia AM et al. Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer Cells. Front Oncol 12:868351 (2022). PubMed: 35433479
- Reina S et al. Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress. Redox Biol 51:102264 (2022). PubMed: 35180474
- Singulani MP et al. Impairment of PGC-1a-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease. Exp Gerontol 133:110882 (2020). PubMed: 32084533
- Li D et al. Quercetin Alleviates Ferroptosis of Pancreatic ß Cells in Type 2 Diabetes. Nutrients 12:N/A (2020). PubMed: 32992479