Anti-VDAC2抗体(ab118872)
Key features and details
- Goat polyclonal to VDAC2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-VDAC2抗体
参阅全部 VDAC2 一抗 -
描述
山羊多克隆抗体to VDAC2 -
宿主
Goat -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig
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免疫原
Synthetic peptide within Human VDAC2 aa 250 to the C-terminus (C terminal) (Cysteine residue). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: P45880-1 -
阳性对照
- Human testis lysate, Human heart tissue.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 98% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab118872于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 32 kDa.
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| IHC-P |
Use a concentration of 2.5 - 5 µg/ml.
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| 说明 |
|---|
|
WB
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 32 kDa. |
|
IHC-P
Use a concentration of 2.5 - 5 µg/ml. |
靶标
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功能
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. -
组织特异性
Expressed in all tissues examined. -
序列相似性
Belongs to the eukaryotic mitochondrial porin family. -
结构域
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. -
细胞定位
Mitochondrion outer membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 282120 Cow
- Entrez Gene: 479255 Dog
- Entrez Gene: 7417 Human
- Entrez Gene: 22334 Mouse
- Entrez Gene: 397659 Pig
- Entrez Gene: 83531 Rat
- Omim: 193245 Human
- SwissProt: P45880 Human
see all -
别名
- B-36 vdac antibody
- FLJ23841 antibody
- hVDAC2 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VDAC2 antibody (ab118872)Immunohistochemical staining of ab118872 at 5 µg/ml staining VDAC2 in Paraffin-embedded Human heart tissue followed by biotinylated anti-Goat IgG secondary antibody, alkaline phosphatasestreptavidin and chromogen
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Western blot - Anti-VDAC2 antibody (ab118872)Anti-VDAC2 antibody (ab118872) at 0.3 µg/ml + Human testis lysate in RIPA buffer at 35 µg
Developed using the ECL technique.
Predicted band size: 32 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab118872 被引用在 2 文献中.
- Triplett JC et al. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta 1852:2213-24 (2015). PubMed: 26248058
- Tanno M et al. Translocation of glycogen synthase kinase-3ß (GSK-3ß), a trigger of permeability transition, is kinase activity-dependent and mediated by interaction with voltage-dependent anion channel 2 (VDAC2). J Biol Chem 289:29285-96 (2014). PubMed: 25187518