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AB60063

Anti-UTP3抗体[2950C2a]

Anti-UTP3 antibody [2950C2a]

0

(1 Review)

|

(2 Publications)

Mouse Monoclonal UTP3 antibody. Suitable for WB and reacts with Recombinant fragment - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human UTP3.

查看别名

CRLZ1, SAS10, UTP3, Something about silencing protein 10, Charged amino acid-rich leucine zipper 1, Disrupter of silencing SAS10, UTP3 homolog, CRL1

1 Images
Western blot - Anti-UTP3 antibody [2950C2a] (AB60063)
  • WB

Unknown

Western blot - Anti-UTP3 antibody [2950C2a] (AB60063)

The molecular weight of the band on the western blot does not correspond to the molecular weight of the natural protein because only a fragment of the protein was used.

All lanes:

Western blot - Anti-UTP3 antibody [2950C2a] (ab60063)

All lanes:

immunising recombinant protein

Predicted band size: 55 kDa

Observed band size: 39 kDa

false

关键信息

宿主种属

Mouse

克隆

Monoclonal

克隆号

2950C2a

亚型

IgG1

不含载体蛋白

No

应用

WB

applications

免疫原

Recombinant Fragment Protein within Human UTP3. The exact immunogen used to generate this antibody is proprietary information.

Q9NQZ2

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
纯化说明
ab60063 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane.
存储溶液
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 1% BSA, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.1136% Disodium hydrogenorthophosphate, 0.03% Tripotassium orthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

UTP3 also known as Utp3p is a component of the small subunit processome involved in ribosome biogenesis. This protein has a mass of approximately 65 kDa and mainly localizes in the nucleolus of eukaryotic cells. UTP3 plays an important role in the early steps of 18S rRNA processing as part of the preribosomal particle assembly. This early involvement is essential for the production of the small ribosomal subunit which impacts protein synthesis.
Biological function summary

UTP3 engages in ribosome assembly interacting with other proteins within the small subunit (SSU) processome complex. This complex processes pre-rRNA into mature rRNA critical for ribosome function. UTP3's role ensures the accuracy and efficiency of rRNA folding and processing which is essential for the assembly of functional ribosomal units in eukaryotic cells.

Pathways

UTP3 is highly involved in the ribosome biogenesis pathway. This pathway is critical for cell growth and proliferation as it directly affects translation and protein synthesis. UTP3 associates with other SSU processome proteins like UTP4 and UTP15 facilitating pre-rRNA processing and ribosome assembly. These interactions highlight UTP3's importance in maintaining the integrity of the protein synthesis machinery.

Abnormalities in UTP3 function can relate to ribosomopathies and cancer. Disruptions in ribosome biogenesis involving proteins like UTP3 can lead to improper cell growth and proliferation often noted in cancers. Additionally any aberration in its interaction with other nucleolar proteins like UTP4 may further impact disease manifestation reflecting UTP3's significance in maintaining cellular homeostasis.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Essential for gene silencing : has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed : 34516797).
See full target information UTP3
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 203:2630-2643 PubMed31586036

2019

Controls Germinal Center Reaction by Relaying a Wnt Signal to the Expression in Centroblasts during Humoral Immune Responses.

Applications

Unspecified application

Species

Unspecified reactive species

Seung Young Choi,Joo Hyun Pi,Sung-Kyun Park,Chang Joong Kang

Stem cell reports 11:756-769 PubMed30174317

2018

The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.

Applications

Unspecified application

Species

Unspecified reactive species

Marco Terrigno,Michele Bertacchi,Luca Pandolfini,Mario Baumgart,Mariantonietta Calvello,Alessandro Cellerino,Michèle Studer,Federico Cremisi
View all publications
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