AB229092

Anti-USP37抗体

Name: USP37抗体 (ab229092)| Abcam中文官网
Brand: Abcam Limited
SKU: AB229092
Price: 4748 CNY
Availability: InStock

Anti-USP37 antibody

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(2 Publications)

Rabbit Polyclonal USP37 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP37.

查看别名

KIAA1594, USP37, Ubiquitin carboxyl-terminal hydrolase 37, Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37

1 Images

Supplier Data

Western blot - Anti-USP37 antibody (AB229092)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-USP37 antibody (ab229092) at 1/1000 dilution

All lanes:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 30 µg

Predicted band size: 110 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Fragment Protein within Human USP37. The exact immunogen used to generate this antibody is proprietary information.

Q86T82

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

USP37 also known as Ubiquitin-Specific Protease 37 is an enzyme that functions as a deubiquitinase. Mechanically it removes ubiquitin from specific protein substrates therefore regulating their degradation by the proteasome. The protein has a mass of approximately 110 kDa. It expresses widely across various tissues with higher levels noticeable in testis brain and placenta which suggests a context-dependent role in different cell types.

Biological function summary

USP37 plays an important role in cell cycle regulation by stabilizing proteins that are key during this process. For example it stabilizes the cyclin A protein which is necessary for the transition between G1/S phases of the cell cycle. USP37 does not function alone; it interacts with other proteins and sometimes becomes part of complexes orchestrating both cellular growth and division by ensuring precise timing and progression within the cell cycle.

Pathways

USP37 is particularly integral to the cell cycle control and DNA damage response pathways. In the cell cycle pathway it closely interacts with Cyclin-dependent kinase 2 (CDK2) regulating transition checkpoints. In the DNA damage response pathway its interaction with proteins like ATR (ataxia telangiectasia and Rad3-related protein) helps maintain genomic integrity by modulating repair processes. These interactions illustrate how USP37 links mechanistic actions to larger functional pathways.

USP37 has implications in oncogenesis and neurodegenerative diseases. Its deregulation may contribute to the development of cancers by affecting the stability of proteins involved in cell proliferation evident in some breast and prostate cancers. In neurodegenerative diseases like Alzheimer’s USP37’s interaction with the protein Tau may influence neurofibrillary tangle formation a hallmark of the disorder. Understanding these connections aids in researching potential therapeutic targets and interventions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Deubiquitinase that plays a role in different processes including cell cycle regulation, DNA replication or DNA damage response (PubMed : 26299517, PubMed : 27296872, PubMed : 31911859, PubMed : 34509474). Antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed : 21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed : 27296872). Plays also an essential role beyond S-phase entry to promote the efficiency and fidelity of replication by deubiquitinating checkpoint kinase 1/CHK1, promoting its stability (PubMed : 34509474). Sustains the DNA damage response (DDR) by deubiquitinating and stabilizing the ATP-dependent DNA helicase BLM (PubMed : 34606619). Mechanistically, DNA double-strand breaks (DSB) promotes ATM-mediated phosphorylation of USP37 and enhances the binding between USP37 and BLM (PubMed : 34606619). Promotes cell migration by deubiquitinating and stabilizing the epithelial-mesenchymal transition (EMT)-inducing transcription factor SNAI (PubMed : 31911859). Plays a role in the regulation of mitotic spindle assembly and mitotic progression by associating with chromatin-associated WAPL and stabilizing it through deubiquitination (PubMed : 26299517).

See full target information USP37

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 13:2323-2341 PubMed37424824

2023

USP37 promotes angiogenesis and metastasis in colorectal cancer by facilitating β-catenin stability.

Applications

Unspecified application

Species

Unspecified reactive species

Dafeng Tong,Jie Yuan,Zhaoming Wang,Enda Yu,Jifu E

BMC molecular and cell biology 21:65 PubMed32928102

2020

Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Jianzhou Liu,Qing Yang,Kevin Chen Xiao,Thomas Dobleman,Shen Hu,Gary Guishan Xiao

View all publications

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Anti-USP37抗体

Anti-USP37 antibody

Western blot - Anti-USP37 antibody (AB229092)