AB188239

Anti-USP26抗体

Name: USP26抗体 (ab188239)| Abcam中文官网
Brand: Abcam Limited
SKU: AB188239
Price: 4606 CNY
Availability: InStock

Anti-USP26 antibody

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal USP26 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human USP26 aa 500-800.

查看别名

Ubiquitin carboxyl-terminal hydrolase 26, Deubiquitinating enzyme 26, Ubiquitin thioesterase 26, Ubiquitin-specific-processing protease 26, USP26

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-USP26 antibody (AB188239)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-USP26 antibody (AB188239)

Immunofluorescent analysis of 3% PFA-fixed U2OS cells overexpressing DDDDK-tagged USP26, labeling USP26 (red) with ab188239 at 1/5000 dilution. Cells were also stained with an Anti-DDDDK tag antibody (green).

Supplier Data

Western blot - Anti-USP26 antibody (AB188239)

Western blot analysis (using ab188239 at a 1/2000 dilution) of immunoprecipitates using 293T cell extracts transfected or not with Flag-USP26

Lane 1 : Input of non-transfected 293 cells

Lane 2 : Input of transfected cells with Flag-USP26

Lane 3 : immunoprecipitate with control serum+protein A sepharose.

Lane 4 : immunoprecipitate with ab188239+ protein A sepharose.

All lanes:

Western blot - Anti-USP26 antibody (ab188239)

Predicted band size: 104 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human USP26 aa 500-800. The exact immunogen used to generate this antibody is proprietary information.

Q9BXU7

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/5000", "ICCIF-species-notes": "<p></p>" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯度

Whole antiserum

存储溶液

Preservative: 0.05% Sodium azide

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

USP26 also known as Ubiquitin Specific Peptidase 26 is an enzyme that removes ubiquitin moieties from specific proteins regulating their degradation localization or activity. USP26 is part of the deubiquitinating enzymes (DUBs) family and has a molecular mass of approximately 104 kDa. It expresses mainly in testicular tissue which indicates its role in reproductive biology.

Biological function summary

The enzyme plays a role in spermatogenesis the process of sperm cell development. It participates in the regulation of the androgen receptor (AR) signaling pathway. By interacting with receptors it stabilizes and modulates their activity contributing to normal testicular function. This connects USP26 to a protein complex involving androgen receptors which are essential for male reproductive health.

Pathways

The deubiquitinating activity of USP26 influences the androgen receptor signaling pathway important for male reproductive processes. In the ubiquitin-proteasome system USP26 modulates the stability of the AR receptor and other proteins related to this pathway which may include factors like HSP90 that aid in receptor activation and stabilization.

Anomalies in USP26 function correlate with male infertility. Mutations or altered expression are linked to disorders in spermatogenesis. This has connections with androgen receptor abnormalities as proper receptor function is necessary for normal sperm production. Studies also find indications that dysregulation may link to prostate cancer where androgen receptor involvement is critical.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed : 20501646, PubMed : 28839133). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (PubMed : 28839133). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (PubMed : 20501646). May play a role in spermatogenesis (PubMed : 34202084).

See full target information USP26

style

left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters 448:52-60 PubMed30763716

2019

USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Li,Honghong Zhou,Rui Zhu,Zhihua Liu

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-USP26抗体

Anti-USP26 antibody

Immunocytochemistry/ Immunofluorescence - Anti-USP26 antibody (AB188239)

Western blot - Anti-USP26 antibody (AB188239)