Anti-Uroplakin III抗体(ab82173)
Key features and details
- Rabbit polyclonal to Uroplakin III
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Uroplakin III抗体
参阅全部 Uroplakin III 一抗 -
描述
兔多克隆抗体to Uroplakin III -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide within Human Uroplakin III aa 250 to the C-terminus (C terminal). The exact sequence is proprietary.
Database link: O75631 -
阳性对照
- Human Bladder
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常规说明
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab82173于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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| WB |
Use at an assay dependent concentration.
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| 说明 |
|---|
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IHC-P
1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
|
WB
Use at an assay dependent concentration. |
靶标
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功能
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. -
组织特异性
Expressed in ureter. -
疾病相关
Defects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy. -
序列相似性
Belongs to the uroplakin-3 family. -
细胞定位
Endoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). - Information by UniProt
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数据库链接
- Entrez Gene: 7380 Human
- Omim: 611559 Human
- SwissProt: O75631 Human
- Unigene: 632787 Human
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别名
- MGC119178 antibody
- OTTHUMP00000028951 antibody
- UP III antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Uroplakin III antibody (ab82173)Formalin-fixed, paraffin-embedded section of Human bladder stained with ab82173 at 1/100 dilution. Incubate primary antibody (ab82173) for 10 minutes at RT.
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Western blot - Anti-Uroplakin III antibody (ab82173)Anti-Uroplakin III antibody (ab82173) at 1/100 dilution + lysate prepared from bladder
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab82173 被引用在 3 文献中.
- Jafree DJ et al. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease. Elife 8:N/A (2019). PubMed: 31808745
- Hou T et al. Aberrant differentiation of urothelial cells in patients with ureteropelvic junction obstruction. Int J Clin Exp Pathol 7:5837-45 (2014). IF ; Human . PubMed: 25337225
- Hicks AN et al. Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): Consequences for mouse bladder development and function. Neurourol Urodyn : (2013). PubMed: 23371862