JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB184772

Anti-URG11抗体

Anti-URG11 antibody

4

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal URG11 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human VWCE aa 400-550.

查看别名

URG11, VWCE, von Willebrand factor C and EGF domain-containing protein, HBV X protein up-regulated gene 11 protein, HBxAg up-regulated gene 11 protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-URG11 antibody (AB184772)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-URG11 antibody (AB184772)

Immunofluorescent analysis of PFA fixed U-2 OS cells labeling URG11 with ab184772 at 4 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-URG11 antibody (AB184772)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-URG11 antibody (AB184772)

Immunohistochemical analysis of paraffin embedded Human liver tissue labeling URG11 with ab184772 at 1/1000.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human VWCE aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

Q96DN2

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Urg11 also known as upregulated gene 11 or LncRNA-URHC is a protein with a molecular weight of approximately 42 kDa. This protein has notable expression in several tissues including the liver and kidney. It plays a significant role at the cellular level by interacting with other proteins to facilitate various molecular processes. Researchers often study URG11 for its involvement in cell proliferation and tumor progression.
Biological function summary

The role of URG11 extends beyond a singular function. This protein contributes to the regulation of cell growth and differentiation indicating its involvement in cellular proliferation and tissue development. URG11 acts in coordination sometimes as part of larger complexes to exert its effects on these biological processes. It interacts with key signaling molecules to influence downstream biological outcomes.

Pathways

URG11 engages prominently in pathways related to cell signaling particularly the Wnt/β-catenin signaling pathway. This involvement sees URG11 interacting with critical proteins like β-catenin impacting gene transcription and cellular adhesion processes. Studies show that URG11 also has ties to pathways concerning cell cycle regulation revealing its interconnectedness with proteins involved in cell cycle progression.

URG11 exhibits a significant association with liver cancer particularly hepatocellular carcinoma. Its overexpression correlates with tumor growth making it a potential biomarker for diagnosis and prognosis. URG11 is also linked to renal diseases where it may influence pathogenesis through interactions with proteins such as β-catenin and other signaling molecules. These connections highlight its role in disease development and suggest potential therapeutic targets.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
See full target information VWCE
style
left-column

文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 14:8464 PubMed38123554

2023

VWCE modulates amino acid-dependent mTOR signaling and coordinates with KICSTOR to recruit GATOR1 to the lysosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Tianyu Zhao,Yuanyuan Guan,Chenchen Xu,Dong Wang,Jialiang Guan,Ying Liu

International journal of molecular sciences 21: PubMed32019179

2020

ADAM12 is A Potential Therapeutic Target Regulated by Hypomethylation in Triple-Negative Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Saioa Mendaza,Ane Ulazia-Garmendia,Iñaki Monreal-Santesteban,Alicia Córdoba,Yerani Ruiz de Azúa,Begoña Aguiar,Raquel Beloqui,Pedro Armendáriz,Marta Arriola,Esperanza Martín-Sánchez,David Guerrero-Setas

PLoS biology 16:e2005903 PubMed30208026

2018

Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast.

Applications

Unspecified application

Species

Unspecified reactive species

Yinuo J Wang,Pavanapuresan P Vaidyanathan,Maria F Rojas-Duran,Namrata D Udeshi,Kristen M Bartoli,Steven A Carr,Wendy V Gilbert
View all publications
style
left-column
style
left-column
style
right-column

搭配使用产品

Primary Antibodies

AB218531

Anti-SEH1L antibody [EPR20851]

RabMAb|Recombinant|Trial Size

Immunoprecipitation - Anti-SEH1L antibody [EPR20851] (AB218531)

  • 0
  • 0
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB150820

Anti-USH1G antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-USH1G antibody (AB150820)

  • 0
  • 0
Primary Antibodies

AB213181

Anti-DEPDC5 antibody [EPR20497-23]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-DEPDC5 antibody [EPR20497-23] (AB213181)

  • 5
  • 2

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com