AB153861

Anti-UPP2 抗体

Name: UPP2抗体 (ab153861)| Abcam中文官网
Brand: Abcam Limited
SKU: AB153861
Price: 4606 CNY
Availability: InStock

Anti-UPP2 antibody

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(2 Publications)

Rabbit Polyclonal UPP2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Uridine phosphorylase 2 aa 1-250.

查看别名

Uridine phosphorylase 2, UPase 2, UrdPase 2, UPP2

1 Images

Unknown

Western blot - Anti-UPP2 antibody (AB153861)

10% SDS PAGE

All lanes:

Western blot - Anti-UPP2 antibody (ab153861) at 1/3000 dilution

Lane 1:

293T whole cell lysate at 30 µg

Lane 2:

A431 whole cell lysate at 30 µg

Lane 3:

HeLa whole cell lysate at 30 µg

Predicted band size: 36 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Fragment Protein within Human Uridine phosphorylase 2 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.

O95045

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The UPP2 protein also known as Uridine Phosphorylase 2 catalyzes the reversible phosphorolysis of uridine to uracil and ribose 1-phosphate. It plays a pivotal role in nucleotide metabolism. The molecular mass of UPP2 is approximately 34 kDa. The protein expresses mainly in the liver and kidney where nucleoside metabolism is highly active indicating its significant involvement in regulating nucleoside homeostasis.

Biological function summary

This enzyme contributes to the salvage pathways of pyrimidine metabolism ensuring efficient recycling of nucleotides. It does not function alone; rather UPP2 can interact with other enzymes involved in nucleotide and nucleoside interconversions. It participates indirectly in pathways that manage nucleic acid degradation and synthesis essential for balancing cellular nucleotide pools.

Pathways

UPP2 plays a role in pyrimidine salvage and catabolic pathways. It involves itself in the conversion processes within these pathways influencing DNA and RNA turnover. The protein aligns closely with enzymes such as uridine phosphorylase 1 (UPP1) which also partake in similar reactions emphasizing their cooperation in maintaining nucleotide balance.

Abnormalities in UPP2 function have implications in cancer and metabolic disorders. Altered expression or activity of UPP2 links to cancerous proliferation through its effect on nucleotide availability. Additionally disruptions in uridine metabolism could relate to certain metabolic syndromes. The interaction between UPP2 and uridine phosphorylase 1 further demonstrates their joint involvement in these conditions highlighting potential targets for therapeutic interventions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed : 12849978, PubMed : 21855639). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (PubMed : 12849978).

See full target information Uridine phosphorylase 2

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature metabolism 5:765-776 PubMed37198474

2023

Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Owen S Skinner,Joan Blanco-Fernández,Russell P Goodman,Akinori Kawakami,Hongying Shen,Lajos V Kemény,Lena Joesch-Cohen,Matthew G Rees,Jennifer A Roth,David E Fisher,Vamsi K Mootha,Alexis A Jourdain

Redox biology 58:102544 PubMed36427397

2022

CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Tian,Yunxin Lu,Jinfei Lin,Miao Chen,Huijuan Qiu,Wancui Zhu,Haohui Sun,Jinsheng Huang,Han Yang,Wuguo Deng

View all publications

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Anti-UPP2 抗体

Anti-UPP2 antibody

Western blot - Anti-UPP2 antibody (AB153861)