AB169188

Anti-UBR3抗体

Name: UBR3抗体 (ab169188)| Abcam中文官网
Brand: Abcam Limited
SKU: AB169188
Price: 4606 CNY
Availability: InStock

Anti-UBR3 antibody

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(1 Publication)

Mouse Polyclonal UBR3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human UBR3 aa 1100 to C-terminus.

查看别名

KIAA2024, ZNF650, UBR3, E3 ubiquitin-protein ligase UBR3, N-recognin-3, RING-type E3 ubiquitin transferase UBR3, Ubiquitin-protein ligase E3-alpha-3, Ubiquitin-protein ligase E3-alpha-III, Zinc finger protein 650

1 Images

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Western blot - Anti-UBR3 antibody (AB169188)

All lanes:

Western blot - Anti-UBR3 antibody (ab169188) at 1 µg/mL

Lane 1:

UBR3 transfected 293T cell lysate (81.51 KDa) at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 14 kDa,212 kDa,22 kDa

Observed band size: 25 kDa,7 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Recombinant Fragment Protein within Human UBR3 aa 1100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6ZT12

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

UBR3 also known as UBR domain-containing protein 3 functions as an important E3 ubiquitin ligase within the N-end rule pathway. It has a molecular mass of approximately 200 kDa. UBR3 is widely expressed with significant expression in the brain heart and skeletal muscle tissues. The protein plays an important role in recognizing and tagging proteins that display destabilizing N-terminal residues for proteasomal degradation a process essential for maintaining protein homeostasis.

Biological function summary

This protein performs essential roles in protein quality control and turnover. UBR3 is part of the ubiquitin-proteasome system and forms part of larger ubiquitin ligase complexes. This system governs the degradation of most intracellular proteins regulating various cellular processes like cell cycle progression and apoptosis. It ensures that damaged or misfolded proteins which could disrupt cellular functions are promptly identified and degraded.

Pathways

The ubiquitin proteasome pathway is one of the most important biological frameworks involving UBR3. This pathway pivotal for regulating protein concentrations and controlling cellular functions connects UBR3 with other proteins such as UBR1 and UBR2 which together function in substrate recognition and ubiquitination. Additionally UBR3 is involved in the N-end rule pathway further tying it to numerous cellular activities related to protein synthesis modification and degradation.

Irregularities in UBR3 function could contribute to neurological conditions and muscular degenerative disorders. Altered activity or expression of UBR3 might lead to Neurological disorders such as certain types of ataxias possibly due to disrupted protein homeostasis in neurons. Connections with proteins like p53 in pathways regulated by ubiquitin ligases also implicate UBR3 in cancer where it could affect cell cycle control and apoptosis thereby influencing tumor growth and progression.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed : 27331610).

See full target information UBR3

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 9:999 PubMed30250269

2018

MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development.

Applications

Unspecified application

Species

Unspecified reactive species

Weizhe Liu,Fang Han,Shuai Qu,Yuanfei Yao,Jianxiang Zhao,Muhammad Luqman Akhtar,Yanpeng Ci,Hao Zhang,Hongfei Li,Yufang Zhao,Lei Yue,Yao Zhang,Changlin Wang,Yu Li

View all publications

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Anti-UBR3抗体

Anti-UBR3 antibody

Western blot - Anti-UBR3 antibody (AB169188)