AB101282

Anti-UBN1抗体

Name: UBN1抗体 (ab101282)| Abcam中文官网
Brand: Abcam Limited
SKU: AB101282
Price: 4606 CNY
Availability: InStock

Anti-UBN1 antibody

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(5 Publications)

Rabbit Polyclonal UBN1 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human UBN1 aa 1050 to C-terminus.

查看别名

Ubinuclein-1, HIRA-binding protein, Protein VT4, Ubiquitously expressed nuclear protein, UBN1

1 Images

Unknown

Western blot - Anti-UBN1 antibody (AB101282)

All lanes:

Western blot - Anti-UBN1 antibody (ab101282) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Lane 4:

293T whole cell lysate at 50 µg

Predicted band size: 122 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

Synthetic Peptide within Human UBN1 aa 1050 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NPG3

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab101282 was affinity purified using an epitope specific to UBN1 immobilized on solid support.

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

UBN1 also known as Ubinuclein-1 plays an important role at the mechanical level in remodeling chromatin structure. It has a mass of approximately 83 kDa. This protein is found predominantly in the nucleus and is widespread across different tissues particularly in tissues with higher cellular turnover. UBN1 works by interacting with other chromatin-associated proteins such as histones to facilitate chromatin alterations that are necessary for various cellular processes.

Biological function summary

UBN1 acts as a participant in the regulation of gene expression. It is a component of the Human Histone Acetyltransferase complex (HBO1 complex) which modifies chromatin by adding acetyl groups to histones enabling a more open chromatin state. This more open state is important for gene transcription and DNA replication. UBN1's role in this complex is significant for the regulation of genes important for cell cycle progression and other essential cellular functions.

Pathways

Various control processes converge at UBN1. It plays a significant role in the epigenetic pathway influencing gene expression through chromatin modification. UBN1 is involved in the DNA replication initiation pathway where it facilitates the assembly of pre-replicative complexes. In these pathways UBN1 is related to proteins such as MCM2-7 which are essential for unwinding DNA during replication.

Aberrant UBN1 activity has been linked to cancer and neurodevelopmental disorders. In cancer dysregulated expression of UBN1 can lead to improper gene regulation contributing to uncontrolled cell growth and proliferation. UBN1 interacts with proteins like c-Myc in oncogenic pathways. Additionally changes in UBN1 function have been associated with neurodevelopmental disorders through its influence on chromatin dynamics affecting genes essential for brain development.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.

See full target information UBN1

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 43:114964 PubMed39509271

2024

HIRA protects telomeres against R-loop-induced instability in ALT cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Michelle Lee Lynskey,Emily E Brown,Ragini Bhargava,Anne R Wondisford,Jean-Baptiste Ouriou,Oliver Freund,Ray W Bowman,Baylee A Smith,Santana M Lardo,Sandra Schamus-Hayes,Sarah J Hainer,Roderick J O'Sullivan

Nature structural & molecular biology 27:1152-1164 PubMed33046907

2020

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.

Applications

Unspecified application

Species

Unspecified reactive species

Song My Hoang,Nicole Kaminski,Ragini Bhargava,Jonathan Barroso-González,Michelle L Lynskey,Laura García-Expósito,Justin L Roncaioli,Anne R Wondisford,Callen T Wallace,Simon C Watkins,Dominic I James,Ian D Waddell,Donald Ogilvie,Kate M Smith,Felipe da Veiga Leprevost,Dattatreya Mellacharevu,Alexey I Nesvizhskii,Jianfeng Li,Dominique Ray-Gallet,Robert W Sobol,Genevieve Almouzni,Roderick J O'Sullivan

Nature structural & molecular biology 27:1057-1068 PubMed32895554

2020

Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Júlia Torné,Dominique Ray-Gallet,Ekaterina Boyarchuk,Mickaël Garnier,Patricia Le Baccon,Antoine Coulon,Guillermo A Orsi,Geneviève Almouzni

Nature communications 9:3103 PubMed30082790

2018

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.

Applications

Unspecified application

Species

Unspecified reactive species

Dominique Ray-Gallet,M Daniel Ricketts,Yukari Sato,Kushol Gupta,Ekaterina Boyarchuk,Toshiya Senda,Ronen Marmorstein,Geneviève Almouzni

Molecular endocrinology (Baltimore, Md.) 29:1426-39 PubMed26305679

2015

Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.

Applications

Unspecified application

Species

Unspecified reactive species

Alicia M Blessing,Sathya Ganesan,Kimal Rajapakshe,Ying Ying Sung,Lakshmi Reddy Bollu,Yan Shi,Edwin Cheung,Cristian Coarfa,Jeffrey T Chang,Donald P McDonnell,Daniel E Frigo

View all publications

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Anti-UBN1抗体

Anti-UBN1 antibody

Western blot - Anti-UBN1 antibody (AB101282)