Key features and details
- Rabbit polyclonal to UBE4B
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
参阅全部 UBE4B 一抗
经测试应用适用于: WB, IHC-Pmore details
预测可用于: Mouse, Cow, Zebrafish
Recombinant fragment containing a sequence corresponding to a region within amino acids 740-1020 of Human UBE4B (NP_006039).
- HepG2 whole cell lysate (ab7900); CA922 xenograft; 293T, A431, H1299, HeLa, Molt-4 and Raji cell lysates
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存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
纯度Immunogen affinity purified
功能Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.
组织特异性Highest expression in ovary, testis, heart and skeletal muscle. Expression is low in colon, thymus and peripheral blood leukocytes. Almost undetectable in lung and spleen.
序列相似性Belongs to the ubiquitin conjugation factor E4 family.
Contains 1 U-box domain.
翻译后修饰Proteolytically cleaved by caspases during apoptosis. Cleaved efficiently at Asp-123 by caspase-6 and granzyme B. Cleaved with approximately 10-fold less efficiency at Asp-109 by caspase-3 and caspase-7.
- Information by UniProt
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ab97697 被引用在 3 文献中.
- Zhu L et al. A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis. EMBO Mol Med 14:e14552 (2022). PubMed: 35174975
- Gireud-Goss M et al. The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion. Mol Cell Neurosci 108:103542 (2020). PubMed: 32841720
- Woodfield SE et al. Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. Genes Cancer 7:13-26 (2016). WB, IHC . PubMed: 27014418