JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB128861

重组Anti-Ube4a抗体[EPR7331]

Anti-Ube4a antibody [EPR7331]

2

(3 Reviews)

|

(3 Publications)

Rabbit Recombinant Monoclonal UBE4A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications.

查看别名

KIAA0126, UBE4A, Ubiquitin conjugation factor E4 A, RING-type E3 ubiquitin transferase E4 A

不同偶联物与剂型 (1)

  • Carrier free

    Anti-Ube4a antibody [EPR7331] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR7331

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, ICC/IF

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/250 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

产品详情

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

style
left-column

性能和储存信息

形式
Liquid
纯度
Tissue culture supernatant
存储溶液
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
储存信息
Stable for 12 months at -20°C
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Ube4a also known as U-box containing E3 ubiquitin protein ligase 4A plays a role in the ubiquitination process. It catalyzes the transfer of ubiquitin molecules to specific substrates tagging them for degradation by the proteasome. Ube4a has an approximate molecular mass of 121 kDa. Researchers have observed its expression in various tissues indicating a potential role in widespread cellular processes.
Biological function summary

Ube4a functions in the regulation of protein quality and turnover. It forms part of a ubiquitin-proteasome system playing an important role in maintaining protein homeostasis within cells. The regulation of protein levels is important for various cellular processes including cell cycle control and signal transduction. Ube4a engages in multi-subunit complexes interacting with other E3 ligases to facilitate substrate ubiquitination.

Pathways

Ube4a integrates into the ubiquitin-proteasome pathway a central component in protein degradation. This pathway is essential for regulating various cellular processes including responses to stress. Ube4a works alongside E1 activating enzymes and E2 conjugating enzymes to deliver ubiquitin to substrates efficiently. Its role within this pathway emphasizes the modulation of protein function and turnover linking it with other proteins like USP5 and UCH37 which are involved in deubiquitination.

Ube4a associates with certain neurological conditions and cancer. Researchers have linked aberrant ubiquitination to the pathology of these diseases indicating the importance of Ube4a in maintaining cellular balance. In neurodegenerative disorders improper Ube4a activity may disrupt protein degradation implicating proteins like Parkin. In some cancer types altered Ube4a expression can affect cell cycle regulation with downstream impacts on other proteins such as p53 highlighting its potential involvement in tumorigenesis.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.
See full target information UBE4A
style
left-column

文献 (3)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 16:e1008773 PubMed32881988

2020

NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings.

Applications

Unspecified application

Species

Unspecified reactive species

Chenxi Li,Di Di,Hui Huang,Xin Wang,Qiqi Xia,Xiaochun Ma,Ke Liu,Beibei Li,Donghua Shao,Yafeng Qiu,Zongjie Li,Jianchao Wei,Zhiyong Ma

Molecular cell 69:866-878.e7 PubMed29499138

2018

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

Applications

Unspecified application

Species

Unspecified reactive species

Keren Baranes-Bachar,Adva Levy-Barda,Judith Oehler,Dylan A Reid,Isabel Soria-Bretones,Ty C Voss,Dudley Chung,Yoon Park,Chao Liu,Jong-Bok Yoon,Wei Li,Graham Dellaire,Tom Misteli,Pablo Huertas,Eli Rothenberg,Kristijan Ramadan,Yael Ziv,Yosef Shiloh

Journal of genetics and genomics = Yi chuan xue ba 45:111-120 PubMed29502958

2018

AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism.

Applications

WB

Species

Human

Chun Song,Han Yan,Hanming Wang,Yan Zhang,Huiqing Cao,Yiqi Wan,Lingbao Kong,Shenghan Chen,Hong Xu,Bingxing Pan,Jin Zhang,Guohuang Fan,Hongbo Xin,Zicai Liang,Weiping Jia,Xiao-Li Tian
View all publications
style
left-column
style
left-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。
style
left-column
style
right-column

关联产品

Select an associated product type
Alternative Product
Primary Antibodies

AB137074

Anti-Ube4a antibody [EPR7332]

primary-antibodies

ube4a-antibody-epr7332-ab137074

3

(2 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com