AB246989

Anti-UBAP2L抗体

Name: UBAP2L抗体 (ab246989)| Abcam中文官网
Brand: Abcam Limited
SKU: AB246989
Price: 5947 CNY
Availability: InStock

Anti-UBAP2L antibody

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Rabbit Polyclonal UBAP2L antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UBAP2L aa 1000-1100.

查看别名

KIAA0144, NICE4, UBAP2L, Ubiquitin-associated protein 2-like, Protein NICE-4, RNA polymerase II degradation factor UBAP2L

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-UBAP2L antibody (AB246989)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-UBAP2L antibody (AB246989)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for UBAP2L (green) using ab246989 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2L antibody (AB246989)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2L antibody (AB246989)

Paraffin-embedded human cerebral cortex tissue stained for UBAP2L using ab246989 at 1/200 dilution in immunohistochemical analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human UBAP2L aa 1000-1100. The exact immunogen used to generate this antibody is proprietary information.

Q14157

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

UBAP2L also known as USP10-associated protein 2-like has a molecular mass of approximately 115 kDa. Mechanically it functions as a translational regulator. This protein is enriched in cellular compartments including the cytoplasm and stress granules. It interacts with multiple proteins and is found in many tissues suggesting a role in cellular stress responses and phase separation events.

Biological function summary

UBAP2L influences stress granule dynamics and protein synthesis under stress conditions. It is important for assembly of these translationally silent granules suggesting its involvement in cell survival. As a part of a larger protein interaction complex UBAP2L contributes to cellular homeostasis. Its interaction partners include G3BP1 which serves as an important player in stress granule nucleation.

Pathways

UBAP2L integrates into the mRNA surveillance pathway and the cellular stress response pathway. It interacts with proteins like USP10 and G3BP1 to facilitate stress granule formation and disassembly critical for proper mRNA metabolism. Through these pathways UBAP2L helps maintain proteostasis under cellular stress affecting translation and decay of mRNA.

UBAP2L has implications in neurodegenerative diseases and cancer. Aberrations in its function contribute to Alzheimer's disease through dysregulated stress granule assembly involving proteins like TDP-43. Additionally it plays a role in tumor progression where alterations in its expression correlate with poor prognosis interacting with oncogenic proteins such as HNRNPA1 linked to metastasis and cellular proliferation.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed : 35633597). Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) (By similarity). Is a regulator of stress granule assembly, required for their efficient formation (PubMed : 29395067, PubMed : 35977029). Required for proper brain development and neocortex lamination (By similarity).

See full target information UBAP2L

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Anti-UBAP2L抗体

Anti-UBAP2L antibody

Immunocytochemistry/ Immunofluorescence - Anti-UBAP2L antibody (AB246989)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBAP2L antibody (AB246989)