AB113

Anti-Tyrosine Hydroxylase抗体

Name: Tyrosine Hydroxylase抗体- Neuronal Marker (ab113)| Abcam中文官网
Brand: Abcam Limited
SKU: AB113
Price: 5173 CNY
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Anti-Tyrosine Hydroxylase antibody - Neuronal Marker

(2 Reviews)

(93 Publications)

Sheep Polyclonal Tyrosine Hydroxylase antibody. Suitable for WB and reacts with Rat samples. Cited in 93 publications. Immunogen corresponding to Native Full Length Protein corresponding to Rat TH.

查看别名

Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, Th

1 Images

Supplier Data

Western blot - Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (AB113)

Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k tyrosine hydroxylase protein.

All lanes:

Western blot - Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab113)

Predicted band size: 58 kDa

false

关键信息

宿主种属

Sheep

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Rat

应用

applications

免疫原

Native Full Length Protein corresponding to Rat TH.

P04177

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200", "WB-species-notes": "<p></p>" }, "Mammals": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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产品详情

ab113 can be used as a marker for dopaminergic and noradrenergic neurons.

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.5 Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.238% HEPES, 0.01% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tyrosine hydroxylase also known as TH is an enzyme that catalyzes the conversion of L-tyrosine to L-DOPA. It weighs approximately 60 kDa. You can find this enzyme expressed mainly in the brain adrenal glands and some peripheral tissues. Commonly studied antibodies include anti-tyrosine hydroxylase or anti-TH. It plays a significant role in the catecholamine biosynthesis pathway serving as the rate-limiting step in dopamine synthesis.

Biological function summary

Tyrosine hydroxylase is essential for synthesizing catecholamines including dopamine norepinephrine and epinephrine. This enzyme associates with other components in the catecholamine biosynthetic pathway. It functions as part of a larger complex within certain cells where its action determines levels of important neurotransmitters. These neurotransmitters help regulate numerous central and peripheral nervous system activities.

Pathways

Tyrosine hydroxylase acts as a critical component in both the dopaminergic and adrenergic pathways. In the dopaminergic pathway tyrosine hydroxylase facilitates dopamine production influencing various physiological processes. The enzyme also correlates with ardrd protein in these pathways allowing fine-tuned control of neurotransmitter synthesis. Proteins related to tyrosine hydroxylase in these pathways include aromatic L-amino acid decarboxylase which further processes L-DOPA into dopamine.

Tyrosine hydroxylase has connections with neurodegenerative diseases like Parkinson's disease and conditions such as dystonia. Dysfunctional expression or activity of this enzyme can lead to dopamine deficiency contributing to the motor symptoms in Parkinson's disease. In dystonia alterations in tyrosine hydroxylase activity affect neurotransmitter balance influencing muscle coordination. The relationship with ardrd protein highlights tyrosine hydroxylase's role in maintaining neural health and it highlights potential areas for therapeutic intervention.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed : 10933781, PubMed : 11922614). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity).

See full target information TH

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文献 (93)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7797 PubMed40841722

2025

Integrating artificial intelligence and optogenetics for Parkinson's disease diagnosis and therapeutics in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Bobae Hyeon,Jaehyun Shin,Jae-Hun Lee,Woori Kim,Jea Kwon,Heeyoung Lee,Dae-Gun Kim,Choong Yeon Kim,Sian Choi,Jae-Woong Jeong,Kwang-Soo Kim,C Justin Lee,Daesoo Kim,Won Do Heo

Iranian journal of basic medical sciences 28:790-798 PubMed40343287

2025

Adropin exerts neuroprotection in an experimental rat model of Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ayse Ozkan,Hande Parlak,Osman Sinen,Mehmet Bulbul,Mutay Aydin Aslan,Aysel Agar

NPJ Parkinson's disease 11:47 PubMed40089519

2025

Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson's disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation.

Applications

Unspecified application

Species

Unspecified reactive species

Chunyan Mu,Kaiquan Shao,Mingyu Su,Yurong Guo,Yuxiang Qiu,Ruiao Sun,Sihan Sun,Yaoyu Sun,Chenkai Liu,Wei Wang,Xiaoling Qin,Chuanxi Tang

Nature. Mental health 2:1018-1031 PubMed39989723

2025

Opioid-induced neuroanatomical, microglial and behavioral changes are blocked by suvorexant without diminishing opioid analgesia.

Applications

Unspecified application

Species

Unspecified reactive species

Ronald McGregor,Ming-Fung Wu,Thomas C Thannickal,Songlin Li,Jerome M Siegel

Journal of neuroinflammation 22:8 PubMed39810216

2025

The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Torrente,Enming J Su,Alí Francisco Citalán-Madrid,Gerald P Schielke,Daniel Magaoay,Mark Warnock,Tamara Stevenson,Kris Mann,Flavie Lesept,Nathalie Delétage,Manuel Blanc,Erin H Norris,Denis Vivien,Daniel A Lawrence

Advanced healthcare materials 14:e2402997 PubMed39494983

2024

Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wisberty J Gordián-Vélez,Kevin D Browne,Jonathan H Galarraga,Dimple Chouhan,John E Duda,Rodrigo A España,H Isaac Chen,Jason A Burdick,D Kacy Cullen

Journal of neurochemistry 169:e16217 PubMed39233365

2024

Relaxin family peptide receptor 3 (RXFP3) expressing cells in the zona incerta/lateral hypothalamus augment behavioural arousal.

Applications

Unspecified application

Species

Unspecified reactive species

Brandon K Richards,Sarah S Ch'ng,Ariel B Simon,Terence Y Pang,Jee Hyun Kim,Andrew J Lawrence,Christina J Perry

eLife 12: PubMed38747563

2024

Functional diversity of dopamine axons in prefrontal cortex during classical conditioning.

Applications

Unspecified application

Species

Unspecified reactive species

Kenta Abe,Yuki Kambe,Kei Majima,Zijing Hu,Makoto Ohtake,Ali Momennezhad,Hideki Izumi,Takuma Tanaka,Ashley Matunis,Emma Stacy,Takahide Itokazu,Takashi R Sato,Tatsuo Sato

Cell reports 42:113491 PubMed38052211

2023

Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system.

Applications

Unspecified application

Species

Unspecified reactive species

Malika S Datta,Yannan Chen,Shradha Chauhan,Jing Zhang,Estanislao Daniel De La Cruz,Cheng Gong,Raju Tomer

Journal of clinical medicine 12: PubMed37834764

2023

Recipient Reaction and Composition of Autologous Sural Nerve Tissue Grafts into the Human Brain.

Applications

Unspecified application

Species

Unspecified reactive species

Isaac Colvett,Anah Gilmore,Samuel Guzman,Aurélie Ledreux,Jorge E Quintero,Dhanunjaya Rao Ginjupally,Julie A Gurwell,John T Slevin,Zain Guduru,Greg A Gerhardt,Craig G van Horne,Ann-Charlotte Granholm

View all publications

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Anti-Tyrosine Hydroxylase抗体

Anti-Tyrosine Hydroxylase antibody - Neuronal Marker

Western blot - Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (AB113)