Anti-Tyrosine Hydroxylase抗体(ab128249)
Key features and details
- Rabbit polyclonal to Tyrosine Hydroxylase
- Suitable for: ELISA, WB
- Reacts with: Drosophila melanogaster
- Isotype: IgG
概述
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产品名称
Anti-Tyrosine Hydroxylase抗体
参阅全部 Tyrosine Hydroxylase 一抗 -
描述
兔多克隆抗体to Tyrosine Hydroxylase -
宿主
Rabbit -
经测试应用
适用于: ELISA, WBmore details -
种属反应性
与反应: Drosophila melanogaster -
免疫原
Synthetic peptide corresponding to an N terminal region of Drosophila melanogaster Tyrosine Hydroxylase (isoform Hypodermal) (Uniprot: P18459).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine -
Concentration information loading... -
纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab128249于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| 说明 |
|---|
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ELISA
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
靶标
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功能
Plays an important role in the physiology of adrenergic neurons. -
组织特异性
Mainly expressed in the brain and adrenal glands. -
通路
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. -
疾病相关
Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls. -
序列相似性
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. - Information by UniProt
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数据库链接
- Entrez Gene: 38746 Drosophila melanogaster
- SwissProt: P18459 Drosophila melanogaster
- Unigene: 3463 Drosophila melanogaster
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别名
- Dystonia 14 antibody
- DYT14 antibody
- DYT5b antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab128249 被引用在 4 文献中.
- Zhuravlev AV et al. LIM-kinase 1 effects on memory abilities and male courtship song in Drosophila depend on the neuronal type. Vavilovskii Zhurnal Genet Selektsii 27:250-263 (2023). PubMed: 37293442
- Shen ZJ et al. MicroRNAs miR-14 and miR-2766 regulate tyrosine hydroxylase to control larval-pupal metamorphosis in Helicoverpa armigera. Pest Manag Sci 78:3540-3550 (2022). PubMed: 35587569
- Zhuravlev AV et al. cd1 Mutation in Drosophila Affects Phenoxazinone Synthase Catalytic Site and Impairs Long-Term Memory. Int J Mol Sci 23:N/A (2022). PubMed: 36293213
- Kasture AS et al. Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems. Int J Mol Sci 19:N/A (2018). PubMed: 29914172