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Neuroscience Neurotransmitter Biogenic Amines Dopamine

Anti-Tyrosine Hydroxylase抗体(ab113)

  • Datasheet
  • SDS
Reviews (2)Q&A (5)References (52)

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Western blot - Anti-Tyrosine Hydroxylase antibody (ab113)

    Key features and details

    • Sheep polyclonal to Tyrosine Hydroxylase
    • Suitable for: WB
    • Reacts with: Rat
    • Isotype: IgG

    选择批间可重复性更高的重组抗体

    Product image
    Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (ab137869)
    • 研究可靠 —— 各批次间结果一致且可重复
    • 长期批量供应 —— 采用重组技术,可实现快速生产
    • 首次实验即可成功 —— 经过大量验证确认了特异性
    • 符合伦理标准 —— 产品不含动物成分

    概述

    • 产品名称

      Anti-Tyrosine Hydroxylase抗体
      参阅全部 Tyrosine Hydroxylase 一抗
    • 描述

      羊多克隆抗体to Tyrosine Hydroxylase
    • 宿主

      Sheep
    • 经测试应用

      适用于: WBmore details
    • 种属反应性

      与反应: Rat
      预测可用于: Mammals
    • 免疫原

      Full length native protein (purified) corresponding to Rat Tyrosine Hydroxylase aa 1 to the C-terminus. SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma (rat)
      Database link: P04177

    • 常规说明

      ab113 can be used as a marker for dopaminergic and noradrenergic neurons.

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    • 形式

      Liquid
    • 存放说明

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • 存储溶液

      pH: 7.50
      Constituents: PBS, 0.01% BSA, 0.87% Sodium chloride, 50% Glycerol, 0.238% HEPES
    • Concentration information loading...
    • 纯度

      Immunogen affinity purified
    • 克隆

      多克隆
    • 同种型

      IgG
    • 研究领域

      • Neuroscience
      • Neurotransmitter
      • Biogenic Amines
      • Dopamine
      • Neuroscience
      • Neurotransmitter
      • Biogenic Amines
      • Noradrenaline
      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Soma marker
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      • Cancer Metabolism
      • Metabolic signaling pathway
      • Hormone biosynthesis
      • Cancer
      • Cancer Metabolism
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      • Endocrine metabolism
      • Hormone biosynthesis
      • Metabolism
      • Types of disease
      • Cancer
      • Neuroscience
      • Development

    相关产品

    • Isotype control

      • Sheep IgG - Isotype Control (ab37385)
    • Recombinant Protein

      • Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278)

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab113于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    1/200. Predicted molecular weight: 60 kDa.
    说明
    WB
    1/200. Predicted molecular weight: 60 kDa.

    靶标

    • 功能

      Plays an important role in the physiology of adrenergic neurons.
    • 组织特异性

      Mainly expressed in the brain and adrenal glands.
    • 通路

      Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
    • 疾病相关

      Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
      Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
    • 序列相似性

      Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    • Target information above from: UniProt accession P07101 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 数据库链接

      • Entrez Gene: 25085 Rat
      • SwissProt: P04177 Rat
      • Unigene: 11082 Rat
      • 别名

        • Dystonia 14 antibody
        • DYT14 antibody
        • DYT5b antibody
        • EC 1.14.16.2 antibody
        • OTTHUMP00000011225 antibody
        • OTTHUMP00000011226 antibody
        • ple antibody
        • Protein Pale antibody
        • TH antibody
        • The antibody
        • TY3H_HUMAN antibody
        • TYH antibody
        • Tyrosine 3 hydroxylase antibody
        • Tyrosine 3 monooxygenase antibody
        • Tyrosine 3-hydroxylase antibody
        • Tyrosine 3-monooxygenase antibody
        • Tyrosine hydroxylase antibody
        see all

      图片

      • Western blot - Anti-Tyrosine Hydroxylase antibody (ab113)
        Western blot - Anti-Tyrosine Hydroxylase antibody (ab113)

        Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k tyrosine hydroxylase protein.

      实验方案

      • Immunohistochemistry protocols
      • Immunocytochemistry & immunofluorescence protocols
      • Western blot protocols

      Click here to view the general protocols

      数据表及文件

      • SDS download

      • Datasheet download

        Download

      文献 (52)

      发表研究结果有使用 ab113?请让我们知道,以便我们可以引用本数据表中的参考文章。

      ab113 被引用在 52 文献中.

      • Al Khazal F  et al. Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency. FASEB J 35:e21227 (2021). PubMed: 33247500
      • Schiller M  et al. Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation. Immunity 54:1022-1036.e8 (2021). PubMed: 33932356
      • Lowes DC  et al. Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice. Nat Commun 12:3539 (2021). PubMed: 34112787
      • Zhang L  et al. MiR-30c-5p/ATG5 Axis Regulates the Progression of Parkinson's Disease. Front Cell Neurosci 15:644507 (2021). PubMed: 34113238
      • Urlic M  et al. Effects of Different n6/n3 PUFAs Dietary Ratio on Cardiac Diabetic Neuropathy. Nutrients 12:N/A (2020). PubMed: 32927766
      View all Publications for this product

      客户评价及客户问答

      Show All 评价 Q&A
      提交评价 提交问题

      1-7 of 7 Abreviews or Q&A

      Immunohistochemistry - Free Floating abreview for Anti-Tyrosine Hydroxylase antibody - Neuronal Marker

      Excellent
      Abreviews
      Abreviews
      abreview image
      Application
      Immunohistochemistry free floating
      Sample
      Mouse Tissue sections (brain slice)
      Specification
      brain slice
      Read More
      The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

      Dr. Xiaobin Liu

      Verified customer

      提交于 Jul 18 2011

      Immunocytochemistry/ Immunofluorescence abreview for Anti-Tyrosine Hydroxylase antibody - Neuronal Marker

      Excellent
      Abreviews
      Abreviews
      abreview image
      Application
      Immunocytochemistry/ Immunofluorescence
      Sample
      Rat Cell (brain)
      Specification
      brain
      Fixative
      Paraformaldehyde
      Read More
      The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

      Prof. Jim Deuchars

      Verified customer

      提交于 May 16 2006

      Question

      Could you please give me another antibody free of charge as you mentioned you can provide in the below message.
      I would like to have Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab113)

      Read More

      Abcam community

      Verified customer

      Asked on Jan 26 2012

      Answer

      Thank you for your email.
      I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number xxx with ab113.
      To check the status of the order please contact our Customer Service team and reference this number.
      Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know.
      I wish you the best of luck with your research.

      Read More

      Abcam Scientific Support

      回复于 Jan 26 2012

      Question

      Does this antibody crossreact with all Histone H1 isoforms?

      Read More

      Abcam community

      Verified customer

      Asked on Jul 25 2007

      Answer

      Thank you for your patience. I have received confirmation from the originator of the product and it seems that there is no specific data on whether the antibody recognizes all isoforms of histone H1, as we do not currently have access to the antigen. This data was originally determined via ELISA. I am sorry I can't be of more assistance in this occasion but should you require any further information, please do not hesitate to contact me.

      Read More

      Abcam Scientific Support

      回复于 Jul 25 2007

      Question

      To my understanding you are selling antibodies from Novus Biologicals. I am interested in either NB 300-108,a monoclonal mouse anti-TH, or NB 300-110, a polyclonal sheep anti-TH antibody. Do you have any idea what antibody would work best for immunohistochemistry on rat brain? I would also like ask about how to order the antibody, prices and how long time before the delivery to Stockholm, Sweden?

      Read More

      Abcam community

      Verified customer

      Asked on Jul 04 2001

      Answer

      Dear Sir: Both of these antibodies can be used for immunocytochemistry and immunohistochemistry. The difference is that the NB300-108 is sensitive enough to stain fibers in the cerebral cortex. The cost of these two antibodies is $175. We would ship these antibodies, using dry ice ($10) and the delivery charge would be $60. This would be a total of $245 (USD). Delivery would take 2 business days to arrive to you from our establishment. I hope this reply answers all of your questions. Best Regards, Kate Lynott, DSO Novus Biologicals, Inc.

      Read More

      Abcam Scientific Support

      回复于 Jul 05 2001

      Question

      Dear Sir, Can this TH-300-110 Ab be used in immunohistochemistry in mouse brain? Best regards, Ling Wang

      Read More

      Abcam community

      Verified customer

      Asked on May 16 2001

      Answer

      The antibody should work for this application. For a reference, see: Lewis, D.A., et al. Four Isoforms of Tyrosine Hydroxylase are Expressed in Human Brain. 54(2): 477-492, 1993.

      Read More

      Abcam Scientific Support

      回复于 May 16 2001

      Question

      We are interested in antibody to human TH. Can you give us the info. on ab-TH-300110. Thanks

      Read More

      Abcam community

      Verified customer

      Asked on Mar 20 2001

      Answer

      raised against native rat - purified from pheochromocytoma, host species is sheep, can be used to detect all mammalian forms,WB gives a band at ~60 kDa [1:200 dilution (S35-protein A)], can be used in IP (1:10), IH, and IC (1:2000),supplied in 15 ug units at 100 ul, each. For more information, please check the www.novus-biolocals.com webpage (catalog # NB300-110).

      Read More

      Abcam Scientific Support

      回复于 Mar 27 2001

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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