AB237697

Anti-TXNDC5抗体

Name: TXNDC5抗体 (ab237697)| Abcam中文官网
Brand: Abcam Limited
SKU: AB237697
Price: 4864 CNY
Availability: InStock

Anti-TXNDC5 antibody

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(2 Publications)

Rabbit Polyclonal TXNDC5 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TXNDC5 aa 1-350.

查看别名

TLP46, UNQ364/PRO700, TXNDC5, Thioredoxin domain-containing protein 5, Endoplasmic reticulum resident protein 46, Thioredoxin-like protein p46, ER protein 46, ERp46

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)

Paraffin-embedded human gastric cancer tissue stained for TXNDC5 with ab237697 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)

Paraffin-embedded human colon cancer tissue stained for TXNDC5 with ab237697 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-TXNDC5 antibody (AB237697)

All lanes:

Western blot - Anti-TXNDC5 antibody (ab237697) at 1/1000 dilution

Lane 1:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Lane 2:

COLO 320 (human colorectal adenocarcinoma cell line) whole cell lysate

Lane 3:

Mouse stomach tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 48 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human TXNDC5 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q8NBS9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TXNDC5 also known as Thioredoxin Domain-Containing Protein 5 is an endoplasmic reticulum-resident protein with a molecular mass of approximately 48 kDa. This protein functions as a disulfide isomerase assisting in the formation and rearrangement of disulfide bonds in newly synthesized proteins. Researchers note its high expression in tissues such as the liver lung and heart where protein folding demands are significant. Due to its involvement in protein folding TXNDC5 maintains cellular homeostasis and assists in proper protein assembly.

Biological function summary

TXNDC5 contributes to the oxidative folding of proteins within the endoplasmic reticulum. The protein does not act alone but as part of a larger complex involving other chaperones and foldases that together ensure protein quality control. TXNDC5 interfaces with the redox system impacting the oxidative environment necessary for correct protein folding. By contributing to this complex system TXNDC5 helps prevent the accumulation of misfolded proteins and maintains the integrity of cellular function.

Pathways

TXNDC5 plays a role in the protein folding pathway which is vital to maintaining cellular stability. In addition its involvement in the response to unfolded protein responses signifies its importance in stress-related pathways. TXNDC5 often interacts with other proteins such as PDI (Protein Disulfide Isomerase) and Calreticulin which are also important in protein folding and cellular stress responses. These pathways are essential for adapting to changes in protein synthesis demands and mitigating the effects of cellular stress.

TXNDC5 has associations with conditions such as rheumatoid arthritis and certain cancers. Aberrant expression levels of TXNDC5 correlate with increased inflammatory responses in rheumatoid arthritis indicating its role in disease progression. In cancer overexpression of this protein has been observed suggesting a potential role in tumor growth and survival. Additionally TXNDC5 interacts with proteins like Hsp70 (Heat Shock Protein 70) which also plays a role in these disorders by assisting in protein folding under stress conditions thereby potentially influencing disease outcomes.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.

See full target information TXNDC5

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Translational cancer research 13:81-101 PubMed38410208

2024

Validation of the interaction between PRDX4 and TXNDC5 in gastric cancer and the significance of the gene in gastric cancer based on a data mining analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Zhang,Kai Wu,Yanhong Hou,Xianghui Li

The Journal of biological chemistry 299:104982 PubMed37390992

2023

Persistent ER stress causes GPI anchor deficit to convert a GPI-anchored prion protein into pro-PrP via the ATF6-miR449c-5p-PIGV axis.

Applications

Unspecified application

Species

Unspecified reactive species

JingFeng Li,SaSa Li,ShuPei Yu,Jie Yang,JingRu Ke,Huan Li,Heng Chen,MingJian Lu,Man-Sun Sy,ZhenXing Gao,Chaoyang Li

View all publications

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Abcam Product Promise

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Anti-TXNDC5抗体

Anti-TXNDC5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TXNDC5 antibody (AB237697)

Western blot - Anti-TXNDC5 antibody (AB237697)