Anti-TRPV2抗体(ab6183)
Key features and details
- Rabbit polyclonal to TRPV2
- Suitable for: IHC-Fr, Dot blot, WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-TRPV2抗体
参阅全部 TRPV2 一抗 -
描述
兔多克隆抗体to TRPV2 -
宿主
Rabbit -
经测试应用
适用于: IHC-Fr, Dot blot, WBmore details -
种属反应性
与反应: Rat -
免疫原
Synthetic peptide corresponding to Rat TRPV2 aa 700-800 (C terminal) conjugated to keyhole limpet haemocyanin (Glutaraldehyde).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7 -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
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| Dot blot |
Use at an assay dependent concentration.
|
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| WB |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
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Dot blot
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
靶标
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功能
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. -
序列相似性
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Contains 6 ANK repeats. -
翻译后修饰
N-glycosylated.
Phosphorylated by PKA. -
细胞定位
Cell membrane. Cytoplasm. Melanosome. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
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数据库链接
- Entrez Gene: 29465 Rat
- SwissProt: Q9WUD2 Rat
- Unigene: 206528 Rat
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别名
- MGC12549 antibody
- Osm 9 like TRP channel 2 antibody
- Osm-9-like TRP channel 2 antibody
see all
数据表及文件
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Datasheet download
文献 (6)
ab6183 被引用在 6 文献中.
- Lana D et al. The Protective Effect of CBD in a Model of In Vitro Ischemia May Be Mediated by Agonism on TRPV2 Channel and Microglia Activation. Int J Mol Sci 23:N/A (2022). PubMed: 36292998
- Elbaz M et al. TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer. Oncotarget 9:33459-33470 (2018). PubMed: 30323891
- Shimohira D et al. TRPV2 expression in rat oral mucosa. Histochem Cell Biol 132:423-33 (2009). IHC-FoFr ; Rat . PubMed: 19579031
- Yamamoto Y et al. Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells. Neurosci Lett 454:129-33 (2009). IHC-Fr ; Rat . PubMed: 19429069
- Yamamoto Y et al. Distribution of TRPV1- and TRPV2-immunoreactive afferent nerve endings in rat trachea. J Anat 211:775-83 (2007). PubMed: 17979952
- Gaudet AD et al. Regulation of TRPV2 by axotomy in sympathetic, but not sensory neurons. Brain Res 1017:155-62 (2004). PubMed: 15261111
