Anti-TRPM8抗体(ab3243)
Key features and details
- Rabbit polyclonal to TRPM8
- Suitable for: WB, IHC-P
- Reacts with: Human, African green monkey
- Isotype: IgG
概述
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产品名称
Anti-TRPM8抗体
参阅全部 TRPM8 一抗 -
描述
兔多克隆抗体to TRPM8 -
宿主
Rabbit -
特异性
Reacts with residues 278-292 and the C terminus sequence of the human trpm8 protein. -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Human, African green monkey -
免疫原
Synthetic peptide corresponding to Human TRPM8.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Affinity purified -
纯化说明
Immunogen affinity purified. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
应用 | Ab评论 | 说明 |
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WB | (1) |
Use at an assay dependent concentration. Predicted molecular weight: 127 kDa.
|
IHC-P |
1/10 - 1/2000.
|
说明 |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 127 kDa. |
IHC-P
1/10 - 1/2000. |
靶标
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功能
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. -
组织特异性
Expressed in prostate. Also expressed in most in prostate tumors. Also expressed in non-prostatic primary tumors such as colon, lung, breast and skin tumors. -
序列相似性
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 79054 Human
- Omim: 606678 Human
- SwissProt: Q7Z2W7 Human
- Unigene: 366053 Human
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别名
- Long transient receptor potential channel 6 antibody
- LTrpC-6 antibody
- LTrpC6 antibody
see all
图片
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Anti-TRPM8 antibody (ab3243) at 1/750 dilution + TRPM8 transfected Cos7 cell lysate
Predicted band size: 127 kDa -
ab3243 staining TRPM8 in human prostate cancer tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).
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All lanes : Anti-TRPM8 antibody (ab3243) at 1000 cells
Lane 1 : Human liver tissue lysate
Lane 2 : Human hepatocyte lysate
Lysates/proteins at 20 µg per lane.
Secondary
All lanes : Goat Anti-Rabbit HRP at 1/1000 dilution
Predicted band size: 127 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (27)
ab3243 被引用在 27 文献中.
- Xu Q et al. Expression of transient receptor potential cation channel subfamily M member 8 in gastric cancer and its clinical significance. Exp Ther Med 21:377 (2021). PubMed: 33680099
- Gao Y et al. Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-?B and TGF-ß1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling. J Ginseng Res 45:408-419 (2021). PubMed: 34025134
- Wen J et al. Thermo-TRPs and gut microbiota are involved in thermogenesis and energy metabolism during low temperature exposure of obese mice. J Exp Biol 223:N/A (2020). PubMed: 32341176
- Silva DF et al. TRPM8 channel activation triggers relaxation of pudendal artery with increased sensitivity in the hypertensive rats. Pharmacol Res 147:104329 (2019). PubMed: 31340190
- Liu T et al. RNA interference-mediated depletion of TRPM8 enhances the efficacy of epirubicin chemotherapy in prostate cancer LNCaP and PC3 cells. Oncol Lett 15:4129-4136 (2018). PubMed: 29541177