Key features and details
- Goat polyclonal to TRPM7
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
参阅全部 TRPM7 一抗
经测试应用适用于: ICC/IFmore details
预测可用于: Dog, Pig
Synthetic peptide: TKESESTNSVRLML, corresponding to C terminal amino acids 1852-1865 of Human TRPM7.
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Please see reference He et al for details of the size of the protein detected by SDS-PAGE. Principal Names: TRPM7; transient receptor potential cation channel, subfamily M, member 7; CHAK; CHAK1; LTRPC7; FLJ20117; TRP-PLIK; LTRPC ion channel family member 7; homolog of mouse transient receptor potential-phospholipase C-interacting kinase CHaK hypothetical protein. Official Gene Symbol - TRPM7 GenBank Accession Number – XP_030709 LocusLink ID - 54822 (human).
Can be blocked with Human TRPM7 peptide (ab22777).
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Concentration information loading...
纯度Immunogen affinity purified
纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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Use at an assay dependent concentration.
Use at an assay dependent concentration.
功能Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
疾病相关Defects in TRPM7 are a cause of susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 (ALS-PDC1) [MIM:105500]; also called amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual.
序列相似性In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.
In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily.
Contains 1 alpha-type protein kinase domain.
- Information by UniProt
- Entrez Gene: 54822 Human
- Omim: 605692 Human
- SwissProt: Q96QT4 Human
- Unigene: 512894 Human
- ALSPDC antibody
- CHAK antibody
- CHAK1 antibody
Immunocytochemistry/ Immunofluorescence analysis of U2OS labeling TRPM7 with ab729 at 10 ug/mL. Cells were fixed with paraformaldehyde and permeabilized with 0.15% Triton. An Alexa Fluor 488 antibody was used as the secondary antibody (2ug/mL). Actin filaments were stained with phalloidin (red) and the nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/mL) followed by Alexa Fluor 488 secondary antibody (2ug/mL).
ab729 被引用在 23 文献中.
- Lee S et al. The Presence and Distribution of TRPM7 in the Canine Mammary Glands. Animals (Basel) 10:N/A (2020). PubMed: 32168794
- Schaller AM et al. Conserved Herpesvirus Kinase ORF36 Activates B2 Retrotransposons during Murine Gammaherpesvirus Infection. J Virol 94:N/A (2020). PubMed: 32404524
- Yalçin E et al. Is there any difference between endometrial hyperplasia and endometrial carcinoma in terms of expression of TRPM2 and TRPM7 ion channels? Turk J Med Sci 49:653-660 (2019). PubMed: 30997980
- Xing J et al. TRPM7 channel inhibition exacerbates pulmonary arterial hypertension through MEK/ERK pathway. Aging (Albany NY) 11:4050-4065 (2019). PubMed: 31219801
- Won J et al. Molecular expression of Mg2+ regulator TRPM7 and CNNM4 in rat odontoblasts. Arch Oral Biol 96:182-188 (2018). PubMed: 30278312