AB51560

Anti-TRPC3抗体

Name: TRPC3抗体 (ab51560)| Abcam中文官网
Brand: Abcam Limited
SKU: AB51560
Price: 6048 CNY
Availability: InStock
Rating: 5 (2 reviews)

Anti-TRPC3 antibody

(2 Reviews)

(18 Publications)

Rabbit Polyclonal TRPC3 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 18 publications. Immunogen corresponding to Synthetic Peptide within Human TRPC3 aa 100-200.

查看别名

TRP3, TRPC3, Short transient receptor potential channel 3, TrpC3, Transient receptor protein 3, TRP-3, hTrp-3, hTrp3

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPC3 antibody (AB51560)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPC3 antibody (AB51560)

Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody ab51560 at 10 µg/ml.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human TRPC3 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q13507

特异性

ab51560 can be used for the detection of TRPC3.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The TRPC3 protein also known as transient receptor potential cation channel subfamily C member 3 is a fundamental component of the plasma membrane and participates in forming a non-selective cation channel. With a molecular mass of approximately 97 kDa TRPC3 channels are widely expressed in the brain heart and vascular smooth muscle. These channels mediate calcium and to a less degree sodium influx when activated facilitating various cellular responses. Additionally TRPC3 channels can interact with other proteins within the same family shaping the channel's functional properties.

Biological function summary

Transient receptor potential channels like TRPC3 play important roles in cellular calcium signaling with direct implications in neuronal cardiac and smooth muscle functions. TRPC3 proteins can assemble into heteromultimeric complexes with other TRPC family members often modulating their biophysical characteristics and responsiveness to stimuli. In neurons TRPC3 channels contribute to synaptic transmission and plasticity by influencing intracellular calcium levels. In smooth muscle cells TRPC3 activity influences contraction and relaxation processes affected by calcium flux regulation.

Pathways

Inositol triphosphate (IP3) and phospholipase C (PLC) pathways notably involve TRPC3 activity. TRPC3 cooperates with the IP3 receptor to mediate calcium release from the endoplasmic reticulum enhancing cellular calcium entry. This interaction ties TRPC3 functionally to the regulation of important physiological processes like cardiac hypertrophy and vascular tone. Additionally TRPC3's relationship with proteins such as calmodulin and STIM1 further illustrates its role in calcium signaling pathways.

Altered TRPC3 activity relates to conditions such as cardiac hypertrophy and neurodegenerative diseases. The protein's dysregulation can result in disrupted calcium homeostasis contributing to excessive cardiac cell growth and potential heart failure. In the nervous system TRPC3 has links to Huntington's disease where its abnormal function associates with neuronal survival and synaptic alterations. The interaction of TRPC3 with proteins such as huntingtin in these pathological contexts highlights its participation in disease development and progression.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Forms a receptor-activated non-selective calcium permeant cation channel (PubMed : 29726814, PubMed : 30139744, PubMed : 35051376, PubMed : 9417057, PubMed : 9930701, PubMed : 10611319).. Isoform 2. Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.

See full target information TRPC3

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文献 (18)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 12:1337714 PubMed38425503

2024

A role for TRPC3 in mammalian testis development.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenhua Ming,Stefan Bagheri-Fam,Emily R Frost,Janelle M Ryan,Vincent R Harley

Environmental toxicology 39:357-366 PubMed37755144

2023

MiRNA-26a-5p inhibits preterm labor initiation by targeting and regulating TRPC3 ion channel protein expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Chen,Tong Liu,Hong Cui,Quan Na,Sishi Liu

International journal of molecular sciences 23: PubMed35008591

2021

Fibroblast Growth Factor 23 Stimulates Cardiac Fibroblast Activity through Phospholipase C-Mediated Calcium Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Wei Lee,Cheng-Chih Chung,Ting-I Lee,Yung-Kuo Lin,Yu-Hsun Kao,Yi-Jen Chen

International journal of molecular sciences 22: PubMed33467715

2021

Lithium Reduces Migration and Collagen Synthesis Activity in Human Cardiac Fibroblasts by Inhibiting Store-Operated Ca Entry.

Applications

Unspecified application

Species

Unspecified reactive species

Pao-Huan Chen,Cheng-Chih Chung,Yuan-Feng Lin,Yu-Hsun Kao,Yi-Jen Chen

The Journal of general virology 101:1090-1102 PubMed32692647

2020

A novel antiviral formulation inhibits a range of enveloped viruses.

Applications

Unspecified application

Species

Unspecified reactive species

Nicola F Fletcher,Luke W Meredith,Emma L Tidswell,Steven R Bryden,Daniel Gonçalves-Carneiro,Yasmin Chaudhry,Claire Shannon-Lowe,Michael A Folan,Daniella A Lefteri,Marieke Pingen,Dalan Bailey,Clive S McKimmie,Alan W Baird

Anesthesiology 133:364-376 PubMed32665491

2020

Transient Receptor Potential Cation Channels and Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia.

Applications

Unspecified application

Species

Unspecified reactive species

Jose Rafael Lopez,Vikas Kaura,Phillip Hopkins,Xiaochen Liu,Arkady Uryach,Jose Adams,Paul D Allen

Molecular neurobiology 56:3313-3325 PubMed30120731

2018

Transcription Factor 2I Regulates Neuronal Development via TRPC3 in 7q11.23 Disorder Models.

Applications

Unspecified application

Species

Unspecified reactive species

Marielle H S Deurloo,Ekaterina Turlova,Wen-Liang Chen,You Wei Lin,Elaine Tam,Nardos G Tassew,Michael Wu,Ya-Chi Huang,Jacqueline N Crawley,Philippe P Monnier,Alexander J A Groffen,Hong-Shuo Sun,Lucy R Osborne,Zhong-Ping Feng

Experimental and therapeutic medicine 16:103-112 PubMed29896230

2018

S-adenosyl methionine regulates calcium channels and inhibits uterine smooth muscle contraction in rats with infectious premature delivery through the transient receptor protein 3/protein kinase Cβ/C-kinase-activated protein phosphatase-1 inhibitor of 17 kDa signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Ge,Tao Han,Xiaoqiu Li,Lili Shan,Jinhuan Zhang,Yan Hong,Yanqiu Xia,Jun Wang,Mingxiao Hou

Frontiers in physiology 9:266 PubMed29628897

2018

Stanniocalcin 2 Regulates Non-capacitative Ca Entry and Aggregation in Mouse Platelets.

Applications

Unspecified application

Species

Mouse

Esther López,L Gómez-Gordo,Carlos Cantonero,Nuria Bermejo,Jorge Pérez-Gómez,María P Granados,Gines M Salido,Juan A Rosado Dionisio,Pedro C Redondo Liberal

Molecular medicine reports 17:898-910 PubMed29115500

2017

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Chen,Dongming Zheng,Hong Cui,Sishi Liu,Lijuan Zhang,Caixia Liu

View all publications

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Anti-TRPC3抗体

Anti-TRPC3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRPC3 antibody (AB51560)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性