AB224583

Anti-Troponin T1/TNT抗体

Name: Troponin T1/TNT抗体 (ab224583)| Abcam中文官网
Brand: Abcam Limited
SKU: AB224583
Price: 5757 CNY
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Anti-Troponin T1/TNT antibody

(1 Review)

(1 Publication)

Rabbit Polyclonal Troponin T1/TNT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TNNT1 aa 1-100.

查看别名

TNT, TNNT1, TnTs, Slow skeletal muscle troponin T, sTnT

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

Negative Control : Paraffin-embedded human lymph node tissue stained for Troponin T1/TNT using ab224583 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

Negative Control : Paraffin-embedded human colon tissue stained for Troponin T1/TNT using ab224583 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

Paraffin-embedded human skeletal muscle tissue stained for Troponin T1/TNT using ab224583 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

Negative Control : Paraffin-embedded human kidney tissue stained for Troponin T1/TNT using ab224583 at 1/500 dilution in immunohistochemical analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human TNNT1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P13805

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Troponin T1 also known as TNT or skeletal muscle Troponin T is an important player in muscle contraction. This protein interacts with actin and tropomyosin to regulate the calcium-mediated contraction process. Troponin T1 has a molecular mass of approximately 36 kDa. It is strongly expressed in skeletal and cardiac muscles. This protein provides critical structural roles linking the components of the troponin complex together which in turn influences muscle contraction efficiency.

Biological function summary

This protein is a component of the troponin complex which also includes the proteins Troponin I and Troponin C. Troponin T1 binds tropomyosin and helps to align the troponin complex along the actin filament. This alignment is needed for the regulation of actin-myosin crossbridge formation. Through these interactions Troponin T1 allows skeletal and cardiac muscles to respond to calcium concentration changes during contraction.

Pathways

Troponin T1 participates mainly in the calcium signaling pathway and plays an important role in muscle contraction pathways. Its interaction with Troponin C affects calcium binding dynamics which is important for muscle contraction cycles. This coordination with Troponin I helps inhibit ATPase activity based on calcium presence ensuring efficient muscle relaxation following contraction.

Mutations in the Troponin T1 gene are linked to skeletal muscle diseases like nemaline myopathy. This condition affects muscle tone and strength mostly impacting infants and children. Troponin mutations also connect to hypertrophic cardiomyopathy a disorder that thickens the heart muscle potentially leading to heart failure. Mutations in genes encoding these proteins can disrupt normal muscle contraction cycles leading to these serious health issues.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

See full target information TNNT1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 41:111571 PubMed36323262

2022

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Katherine M Hannan,Priscilla Soo,Mei S Wong,Justine K Lee,Nadine Hein,Perlita Poh,Kira D Wysoke,Tobias D Williams,Christian Montellese,Lorey K Smith,Sheren J Al-Obaidi,Lorena Núñez-Villacís,Megan Pavy,Jin-Shu He,Kate M Parsons,Karagh E Loring,Tess Morrison,Jeannine Diesch,Gaetan Burgio,Rita Ferreira,Zhi-Ping Feng,Cathryn M Gould,Piyush B Madhamshettiwar,Johan Flygare,Thomas J Gonda,Kaylene J Simpson,Ulrike Kutay,Richard B Pearson,Christoph Engel,Nicholas J Watkins,Ross D Hannan,Amee J George

View all publications

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Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-Troponin T1/TNT抗体

Anti-Troponin T1/TNT antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Troponin T1/TNT antibody (AB224583)