AB193546

Anti-Troponin T1/TNT抗体

Name: Troponin T1/TNT抗体 (ab193546)| Abcam中文官网
Brand: Abcam Limited
SKU: AB193546
Price: 4606 CNY
Availability: InStock

Anti-Troponin T1/TNT antibody

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(2 Publications)

Rabbit Polyclonal Troponin T1/TNT antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TNNT1 aa 150-250.

查看别名

TNT, TNNT1, TnTs, Slow skeletal muscle troponin T, sTnT

1 Images

Supplier Data

Western blot - Anti-Troponin T1/TNT antibody (AB193546)

All lanes:

Western blot - Anti-Troponin T1/TNT antibody (ab193546)

Lane 1:

A549 whole cell lysate

Lane 2:

sp2/0 whole cell lysate

Lane 3:

Rat skeletal muscle tissue lysate

Predicted band size: 33 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Rat, Human

应用

applications

免疫原

Synthetic Peptide within Human TNNT1 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

P13805

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab193546 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

存储溶液

Preservative: 0.1% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Troponin T1 also known as TNT or skeletal muscle Troponin T is an important player in muscle contraction. This protein interacts with actin and tropomyosin to regulate the calcium-mediated contraction process. Troponin T1 has a molecular mass of approximately 36 kDa. It is strongly expressed in skeletal and cardiac muscles. This protein provides critical structural roles linking the components of the troponin complex together which in turn influences muscle contraction efficiency.

Biological function summary

This protein is a component of the troponin complex which also includes the proteins Troponin I and Troponin C. Troponin T1 binds tropomyosin and helps to align the troponin complex along the actin filament. This alignment is needed for the regulation of actin-myosin crossbridge formation. Through these interactions Troponin T1 allows skeletal and cardiac muscles to respond to calcium concentration changes during contraction.

Pathways

Troponin T1 participates mainly in the calcium signaling pathway and plays an important role in muscle contraction pathways. Its interaction with Troponin C affects calcium binding dynamics which is important for muscle contraction cycles. This coordination with Troponin I helps inhibit ATPase activity based on calcium presence ensuring efficient muscle relaxation following contraction.

Mutations in the Troponin T1 gene are linked to skeletal muscle diseases like nemaline myopathy. This condition affects muscle tone and strength mostly impacting infants and children. Troponin mutations also connect to hypertrophic cardiomyopathy a disorder that thickens the heart muscle potentially leading to heart failure. Mutations in genes encoding these proteins can disrupt normal muscle contraction cycles leading to these serious health issues.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

See full target information TNNT1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

European journal of histochemistry : EJH 68: PubMed38686889

2024

Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Chaojie He,Yi Yu,Feifan Wang,Wudi Li,Hui Ni,Meixiang Xiang

Microbiome 11:41 PubMed36869365

2023

Maternal effects drive intestinal development beginning in the embryonic period on the basis of maternal immune and microbial transfer in chickens.

Applications

Unspecified application

Species

Unspecified reactive species

Haizhou Gong,Taiping Wang,Min Wu,Qianran Chu,Hainan Lan,Wuying Lang,Lingyu Zhu,Yang Song,Yujie Zhou,Qiongyi Wen,Jing Yu,Baolin Wang,Xin Zheng

View all publications

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Anti-Troponin T1/TNT抗体

Anti-Troponin T1/TNT antibody

Western blot - Anti-Troponin T1/TNT antibody (AB193546)