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AB96073

Anti-Tropomyosin 2抗体

Anti-Tropomyosin 2 antibody

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(2 Publications)

Rabbit Polyclonal Tropomyosin 2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TPM2 aa 1-300.

查看别名

TMSB, TPM2, Tropomyosin beta chain, Beta-tropomyosin, Tropomyosin-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tropomyosin 2 antibody (AB96073)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tropomyosin 2 antibody (AB96073)

ab96073, at 1/100 dilution, staining Tropomyosin 2 in SW480 xenograft tissue by Immunohistochemistry. Formalin-fixed, paraffin-embedded section.

Western blot - Anti-Tropomyosin 2 antibody (AB96073)
  • WB

Unknown

Western blot - Anti-Tropomyosin 2 antibody (AB96073)

10% SDS PAGE

All lanes:

Western blot - Anti-Tropomyosin 2 antibody (ab96073) at 1/1000 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 33 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human TPM2 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

P07951

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替代产品

Primary Antibodies

AB180176

Anti-Tropomyosin 2 antibody [EPR12846] - C-terminal

RabMAb|Recombinant|Trial Size

Immunoprecipitation - Anti-Tropomyosin 2 antibody [EPR12846] - C-terminal (AB180176)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB113692

Anti-Tropomyosin 3 antibody [3D5AH3AB4]

BOND RX™ Validated|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Tropomyosin 3 antibody [3D5AH3AB4] (AB113692)

  • 4
  • 1
Primary Antibodies

AB170904

Anti-P Glycoprotein antibody [EPR10364-57]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

  • 4
  • 12
Primary Antibodies

AB52866

Anti-alpha Tubulin antibody [EP1332Y] - Loading Control

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-alpha Tubulin antibody [EP1332Y] - Loading Control (AB52866)

  • 5
  • 31
Primary Antibodies

AB955

Anti-CD68 antibody [KP1]

Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD68 antibody [KP1] (AB955)

  • 4
  • 48
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Tropomyosin 2 (TPM2) is a protein that plays an important mechanical role in muscle function. It is a component of the actin filament system weighing approximately 32.7 kDa. TPM2 interacts with actin to stabilize the filament structures which are essential in muscle contraction processes. This protein is expressed mainly in muscle tissues including skeletal and cardiac muscles but is also present in other tissues. Its stability and interaction with actin filaments make it significant in maintaining sarcomere structure.
Biological function summary

TPM2 ensures proper muscle contraction by regulating the interaction between actin and myosin two key components in muscle movement. It forms a complex with actin and troponin a critical protein that regulates muscle contraction through calcium ion binding. This complex facilitates muscle fiber contraction by exposing the binding sites for myosin on actin filaments. The presence of TPM2 in the complex is essential for the contraction mechanism allowing precise control of muscle movements.

Pathways

TPM2 acts in the regulation of muscle contraction and actin cytoskeleton signaling pathways. In the muscle contraction pathway TPM2 interacts closely with tropomyosin 1 (TPM1) and the myosin motor protein playing a regulatory role. It is involved in the actin cytoskeleton signaling pathway where it helps organize actin filaments necessary for various cellular activities. Through these pathways TPM2 integrates signals essential for muscle activity and cellular architecture maintenance.

TPM2 mutations have a notable connection to conditions such as nemaline myopathy and distal arthrogryposis. Nemaline myopathy is characterized by muscle weakness and it arises due to defects in sarcomere proteins with TPM2 being a significant player. Additionally changes in TPM2 can associate with contractures and joint deformities in distal arthrogryposis. The protein connects to cellular disorders through its interactions with troponin I (TNNI2) and other structural sarcomere components highlighting its critical role in muscle integrity and function.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization.
See full target information TPM2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

JHEP reports : innovation in hepatology 7:101543 PubMed41070100

2025

Isolation and immortalization of human portal vein endothelial cells: A novel research tool for studying splanchnic vasculature.

Applications

Unspecified application

Species

Unspecified reactive species

Aina Anton,Sarah Shalaby,Júlia Campalans,Annabel Blasi,Yiliam Fundora,Rosa Montañés,Héctor García-Calderó,Lixin Sun,Joana Codina,Josepmaria Argemí,Olga Tura-Ceide,Joan Carles García-Pagán,Genís Campreciós,Virginia Hernández-Gea

Oncotarget 8:9067-9078 PubMed27391067

2016

A dose-dependent perturbation in cardiac energy metabolism is linked to radiation-induced ischemic heart disease in Mayak nuclear workers.

Applications

WB

Species

Unspecified reactive species

Omid Azimzadeh,Tamara Azizova,Juliane Merl-Pham,Vikram Subramanian,Mayur V Bakshi,Maria Moseeva,Olga Zubkova,Stefanie M Hauck,Nataša Anastasov,Michael J Atkinson,Soile Tapio
View all publications
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