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AB70747

Anti-TRIP6抗体

Anti-TRIP6 antibody

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(3 Publications)

Rabbit Polyclonal TRIP6 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TRIP6.

查看别名

OIP1, TRIP6, Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6, Opa-interacting protein 1, Zyxin-related protein 1, OIP-1, ZRP-1

2 Images
Immunoprecipitation - Anti-TRIP6 antibody (AB70747)
  • IP

Unknown

Immunoprecipitation - Anti-TRIP6 antibody (AB70747)

1mg whole cell lysate from HeLa cells was immunprecipitated using ab70747 at 3µg/mg of lysate. For the subsequent western blot, 20% of the immunoprecipitate was probed with ab70747 at 1ug/ml. Detection : chemiluminescence with exposure time of 10 seconds.

All lanes:

Immunoprecipitation - Anti-TRIP6 antibody (ab70747)

Predicted band size: 50 kDa

false

Western blot - Anti-TRIP6 antibody (AB70747)
  • WB

Unknown

Western blot - Anti-TRIP6 antibody (AB70747)

All lanes:

Western blot - Anti-TRIP6 antibody (ab70747) at 0.04 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Lane 4:

293T whole cell lysate at 50 µg

Predicted band size: 50 kDa

Observed band size: 55 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB, IP

applications

免疫原

Synthetic Peptide within Human TRIP6. The exact immunogen used to generate this antibody is proprietary information.

Q15654

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替代产品

Primary Antibodies

AB137478

Anti-TRIP6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRIP6 antibody (AB137478)

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搭配使用产品

Primary Antibodies

AB198786

Anti-CHRDL2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHRDL2 antibody (AB198786)

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Primary Antibodies

AB211631

Anti-CRP-1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRP-1 antibody - C-terminal (AB211631)

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  • 0
Primary Antibodies

AB192999

Anti-ARS2 antibody - N-terminal

Immunoprecipitation - Anti-ARS2 antibody - N-terminal (AB192999)

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  • 0
Primary Antibodies

AB70454

Anti-DHX15/prp43 antibody

Immunoprecipitation - Anti-DHX15/prp43 antibody (AB70454)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRIP6 also known as Thyroid Hormone Receptor Interactor 6 or ZRP-1 (Zyxin Related Protein 1) is a cytoskeletal adaptor protein with a molecular mass of approximately 55 kDa. Its primary function involves acting as a scaffold protein that facilitates interactions between several intracellular signaling molecules. TRIP6 localizes mainly to focal adhesion sites and the actin cytoskeleton where it regulates cell motility and organization. This protein is usually expressed in various tissues but expression levels are notably prominent in the lymphoid tissues and the gastrointestinal tract.
Biological function summary

The mechanical interactions of TRIP6 influence cell migration adhesion and morphogenesis. It functions as a component of the focal adhesion complex where it plays an important role in linking the actin cytoskeleton to integrin receptors. Additionally TRIP6 participates in the regulation of gene expression by translocating to the nucleus and interacting with transcription factors to modulate specific gene targets.

Pathways

The involvement of TRIP6 is significant within signaling pathways such as the RhoA pathway and the NF-kB signaling pathway. Through RhoA TRIP6 contributes to the modulation of cell shape and motility impacting cellular processes such as angiogenesis and wound healing. In the NF-kB pathway TRIP6 can influence inflammatory responses by affecting gene transcription. TRIP6 is associated with proteins like paxillin and focal adhesion kinase (FAK) which are key components in these pathways.

TRIP6 has notable implications in cancer progression and inflammatory diseases. It has been implicated as a contributor to tumorigenesis due to its role in cell motility and invasion often showing altered expression in various cancers such as breast and prostate cancer. TRIP6 also interacts with the protein zyxin and this interaction influences cancer cell metastasis. Additionally TRIP6 can affect inflammatory responses in disorders such as inflammatory bowel disease where its modulation impacts cellular pathways related to inflammation and immune response.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
See full target information TRIP6
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of cell science : PubMed33558314

2021

TRIP6 is required for tension at adherens junctions.

Applications

Unspecified application

Species

Unspecified reactive species

Srividya Venkatramanan,Consuelo Ibar,Kenneth D Irvine

Experimental and therapeutic medicine 19:2317-2325 PubMed32104300

2020

TRIP6 regulates the proliferation, migration, invasion and apoptosis of osteosarcoma cells by activating the NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Liu,Li Cheng,Qingning Li,Juehua Jing

Cancer research 79:3332-3346 PubMed31018940

2019

TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyan Gou,Jessie Qiaoyi Liang,Lijing Zhang,Huarong Chen,Yanquan Zhang,Rui Li,Xiaohong Wang,Jiafu Ji,Joanna H Tong,Ka-Fai To,Joseph J Y Sung,Francis K L Chan,Jing-Yuan Fang,Jun Yu
View all publications
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