AB174268

重组Anti-TRIML1抗体[EPR12520]

Anti-TRIML1 antibody [EPR12520]

RabMAb
Recombinant
了解详情

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(1 Publication)

Rabbit Recombinant Monoclonal TRIML1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

查看别名

RNF209, TRIML1, Probable E3 ubiquitin-protein ligase TRIML1, RING finger protein 209, RING-type E3 ubiquitin transferase TRIML1, Tripartite motif family-like protein 1

1 Images

Supplier Data

Western blot - Anti-TRIML1 antibody [EPR12520] (AB174268)

All lanes:

Western blot - Anti-TRIML1 antibody [EPR12520] (ab174268) at 1/1000 dilution

Lane 1:

293T lysates at 10 µg

Lane 2:

Human placenta lysates at 10 µg

Predicted band size: 53 kDa

false

不同偶联物与剂型 (1)

Carrier free

Anti-TRIML1 antibody [EPR12520] - BSA and Azide free

关键信息

宿主种属

Rabbit

克隆

Monoclonal

克隆号

EPR12520

亚型

IgG

不含载体蛋白

反应种属

Human

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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产品详情

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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性能和储存信息

形式

Liquid

纯度

Tissue culture supernatant

存储溶液

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRIML1 also known as Tripartite Motif Containing Like 1 is a protein involved in E3 ubiquitin ligase activity. The protein promotes ubiquitination by attaching ubiquitin molecules to substrate proteins tagging them for various cellular fates. TRIML1 weighs approximately 74 kDa and it is expressed in various tissues including immune cells and specific brain regions. The protein’s modular structure consists of a RING finger domain B-boxes and a coiled-coil region which aids in its regulatory functions.

Biological function summary

The protein plays a role in immune response regulation and maintaining protein homeostasis. TRIML1 does not exist as part of a large complex but interacts directly with specific substrates and signaling molecules. The RING finger domain facilitates its binding to E2 ubiquitin-conjugating enzyme enhancing its function in protein degradation and signal transduction. Furthermore TRIML1 modulates inflammation by its action on pro-inflammatory signaling pathways.

Pathways

TRIML1 is engaged mainly in the ubiquitin-proteasome system and the inflammatory signaling pathways. In the context of the ubiquitin-proteasome system TRIML1 influences protein turnover and cellular responses to stress. Additionally it participates in the regulation of NF-kB signaling which is essential for inflammatory responses. Its interactions with proteins such as UBE2D serve as critical connections in these pathways assisting in both protein ubiquitination and inflammatory regulation.

TRIML1 shows connections particularly to neurodegenerative diseases and certain immune disorders. Alterations in TRIML1 expression or function can contribute to proteostasis imbalances implicated in disorders such as Alzheimer's disease. The protein's influence on inflammatory pathways suggests a potential role in autoimmune conditions. In these contexts proteins like NF-kB become highly relevant as both TRIML1 and NF-kB coordinate immune signaling which can exacerbate or mitigate disease development.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.

See full target information TRIML1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 10:644 PubMed31501420

2019

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ya Liu,Xiao Zhang,Jiafei Lin,Yuxin Chen,Yongxia Qiao,Susu Guo,Yueyue Yang,Guoqing Zhu,Qiuhui Pan,Jiayi Wang,Fenyong Sun

View all publications

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Abcam Product Promise

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详情请参阅我们的条款与条件。

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For licensing inquiries, please contact partnerships@abcam.com

重组Anti-TRIML1抗体[EPR12520]