Anti-TRIM71/LIN41抗体(ab105330)
Key features and details
- Rabbit polyclonal to TRIM71/LIN41
- Suitable for: WB, ICC
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TRIM71/LIN41抗体 -
描述
兔多克隆抗体to TRIM71/LIN41 -
宿主
Rabbit -
经测试应用
适用于: WB, ICCmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human TRIM71/LIN41 (C terminal).
Database link: Q2Q1W2 -
阳性对照
- Human brain tissue lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105330于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | (2) |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 93 kDa.
|
| ICC |
Use a concentration of 5 - 20 µg/ml.
|
| 说明 |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 93 kDa. |
|
ICC
Use a concentration of 5 - 20 µg/ml. |
靶标
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功能
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. -
组织特异性
Specifically expressed in testis. -
通路
Protein modification; protein ubiquitination. -
序列相似性
Belongs to the TRIM/RBCC family.
Contains 2 B box-type zinc fingers.
Contains 1 filamin repeat.
Contains 6 NHL repeats.
Contains 1 RING-type zinc finger. -
翻译后修饰
Autoubiquitinated. -
细胞定位
Cytoplasm, P-body. - Information by UniProt
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数据库链接
- Entrez Gene: 131405 Human
- SwissProt: Q2Q1W2 Human
- Unigene: 113170 Human
- Unigene: 567678 Human
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别名
- 2610206G21Rik antibody
- Abnormal cell LINeage LIN 41 antibody
- AL022943 antibody
see all
图片
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Western blot - Anti-TRIM71/LIN41 antibody (ab105330)Lane 1 : Anti-TRIM71/LIN41 antibody (ab105330) at 1 µg/ml
Lane 2 : Anti-TRIM71/LIN41 antibody (ab105330) at 2 µg/ml
All lanes : Human brain tissue lysate
Lysates/proteins at 15 µg per lane.
Secondary
All lanes : Anti-rabbit secondary antibody
Predicted band size: 93 kDa -
Immunocytochemistry - Anti-TRIM71/LIN41 antibody (ab105330)Immunohistochemistry of TRIM71/LIN41 in human brain tissue with ab105330 at 5 µg/ml.
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Immunocytochemistry - Anti-TRIM71/LIN41 antibody (ab105330)Immunofluorescence of TRIM71/LIN41 in Human Brain cells using ab105330 at 20 ug/ml.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab105330 被引用在 2 文献中.
- Han F et al. MicroRNA-4491 enhances cell proliferation and inhibits cell apoptosis in non-small cell lung cancer via targeting TRIM7. Oncol Lett 22:591 (2021). PubMed: 34149902
- Robinton DA et al. The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Dev Cell 48:396-405.e3 (2019). PubMed: 30661985