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AB4527

Anti-TRIM4抗体

Anti-TRIM4 antibody

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(1 Publication)

Goat Polyclonal TRIM4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TRIM4 aa 450 to C-terminus.

查看别名

RNF87, TRIM4, E3 ubiquitin-protein ligase TRIM4, RING finger protein 87, RING-type E3 ubiquitin transferase TRIM4, Tripartite motif-containing protein 4

1 Images
Western blot - Anti-TRIM4 antibody (AB4527)
  • WB

Unknown

Western blot - Anti-TRIM4 antibody (AB4527)

ab4527 staining (1ug/ml) of HepG2 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot using chemiluminescence.

ab4527 staining (1ug/ml) of HepG2 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot using chemiluminescence.

All lanes:

Western blot - Anti-TRIM4 antibody (ab4527)

Predicted band size: 57 kDa

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关键信息

宿主种属

Goat

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

WB

applications

免疫原

Synthetic Peptide within Human TRIM4 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9C037

特异性

This antibody is expected to recognise both human isoforms.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>A 1 hour primary incubation is recommended for this product.</p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
存储溶液
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRIM4 also known as tripartite motif-containing protein 4 is a protein that functions mechanically as an E3 ubiquitin-protein ligase. It facilitates the attachment of ubiquitin molecules onto specific substrate proteins marking them for proteasomal degradation. TRIM4 has a molecular mass of approximately 57 kDa. It is expressed in various tissues with notable expression in immune system-related tissues such as the spleen and lymph nodes.
Biological function summary

TRIM4 participates in the regulation of innate immune responses and antiviral defense. It is not known to be a component of large multi-protein complexes instead acting more autonomously. The protein helps in modulating the levels of interferon and other cytokines which are important for the body's antiviral response. Its ability to interact with signaling molecules like MAVS influences its role in immune regulation.

Pathways

TRIM4 plays an important role in the immune signaling cascade. It is involved in the RIG-I-like receptor signaling pathway where it helps amplify antiviral signaling in response to pathogen detection. The protein interacts with other molecules in the pathway including RIG-I and TBK1 to promote the production of antiviral cytokines. These interactions establish TRIM4's position as an important player in the maintenance of immune homeostasis during viral infections.

TRIM4 has associations with certain viral infections and autoimmune disorders. Altered regulation or expression of TRIM4 is linked to conditions characterized by dysregulation of immune responses such as systemic lupus erythematosus (SLE). The function of TRIM4 in these conditions can be modulated by interactions with proteins like IRF3 which are critical for the control of inflammatory responses. Understanding TRIM4's role can facilitate the development of therapeutic strategies in targeting immune-related diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.
See full target information TRIM4
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Human molecular genetics 21:3883-95 PubMed22678061

2012

Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Maxime Feyeux,Fany Bourgois-Rocha,Amanda Redfern,Peter Giles,Nathalie Lefort,Sophie Aubert,Caroline Bonnefond,Aurore Bugi,Marta Ruiz,Nicole Deglon,Lesley Jones,Marc Peschanski,Nicholas D Allen,Anselme L Perrier
View all publications
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