JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB264189

Anti-TRIM37/MUL抗体

Anti-TRIM37/MUL antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal TRIM37/MUL antibody. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM37 aa 850-900.

查看别名

KIAA0898, MUL, POB1, TRIM37, E3 ubiquitin-protein ligase TRIM37, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37

1 Images
Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264189)
  • IP

Supplier Data

Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264189)

TRIM37/MUL was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) using ab264189 at 3 μg/mg lysate. An alternative TRIM37/MUL antibody was used for western blotting at 1 μg/ml.

Lane 1 : ab264189 IP in HeLa whole cell lysate.
Lane 2 : Control IgG IP in HeLa whole cell lysate.

Detection : Chemiluminescence with an exposure time of 3 seconds.

All lanes:

Immunoprecipitation - Anti-TRIM37/MUL antibody (ab264189)

Predicted band size: 108 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IP

applications

免疫原

Synthetic Peptide within Human TRIM37 aa 850-900. The exact immunogen used to generate this antibody is proprietary information.

O94972

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mL", "IP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
+4°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRIM37 also known as MUL is an E3 ubiquitin-protein ligase with a molecular mass of approximately 130 kDa. This protein plays a role in the ubiquitination process which involves labeling proteins for degradation by the proteasome. TRIM37 is widely expressed in various tissues with higher levels seen in the brain liver and heart. The protein contains a RING domain which is important for its ligase activity and mediates the attachment of ubiquitin molecules to substrate proteins therefore controlling the stability and turnover of various cellular proteins.
Biological function summary

TRIM37 regulates processes that are important for cell growth and division as well as for maintaining cellular homeostasis. It functions as part of a larger complex involved in the ubiquitin-proteasome pathway which helps to control protein degradation and recycling within the cell. Through its role in ubiquitination TRIM37 modulates the levels of proteins that are critical for controlling cell cycle progression and responding to stress. Additionally TRIM37 is involved in organizing centrosomes structures that play an important role in chromosome segregation during cell division.

Pathways

TRIM37 interacts with cellular pathways controlling autophagy and the DNA damage response. It contributes to autophagy by regulating proteins that control the formation and clearance of autophagosomes such as ULK1. In the DNA damage response TRIM37 modulates repair processes by regulating the stability of proteins like FANCD2 which is involved in the repair of DNA crosslinks. This illustrates how TRIM37 fits into wider networks inside the cell and influences processes important for maintaining genome integrity.

TRIM37 mutations are linked with Mulibrey nanism a rare growth disorder characterized by multi-organ fibrosis and growth failure. Abnormal functioning of TRIM37 disrupts the regulation of cellular proteins that maintain organ size and structure. Furthermore TRIM37 may play a role in the development of some cancers including breast cancer. In this context the protein can influence cancer progression by modifying the stability of oncogenes or tumor suppressors such as p53 adding further complexity to how TRIM37 impacts disease states.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed : 15885686, PubMed : 23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed : 23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression : associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed : 25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472' : monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed : 28724525). Has anti-HIV activity (PubMed : 24317724).
See full target information TRIM37
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:159 PubMed39901028

2025

Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Min Li,Longhui Hu,Qiao Ke,Zhao Li,Chujun Ruan,Hanjing Lu,Xiaoran Liu

Andrology 12:643-654 PubMed37644905

2023

The role of hepatitis B virus surface protein in inducing Sertoli cell ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chengshuang Pan,Xiangbin Kong,Zhigang Wu,Qianjin Fei
View all publications
style
left-column
style
left-column
style
right-column

替代产品

Primary Antibodies

AB264190

Anti-TRIM37/MUL antibody

Immunoprecipitation - Anti-TRIM37/MUL antibody (AB264190)

  • 0
  • 0
Primary Antibodies

AB238156

Anti-TRIM37/MUL antibody

Immunocytochemistry/ Immunofluorescence - Anti-TRIM37/MUL antibody (AB238156)

  • 0
  • 0

搭配使用产品

Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB192890

Anti-LC3B antibody [EPR18709] - Autophagosome Marker

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-LC3B antibody [EPR18709] - Autophagosome Marker (AB192890)

  • 5
  • 19

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com