Anti-TRIM30/Rpt1抗体

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The protein TRIM30 acts as an E3 ubiquitin ligase an important component in the regulation of protein degradation processes. It facilitates the attachment of ubiquitin molecules to specific substrate proteins targeting them for proteasomal degradation and modulating various cellular activities. TRIM30 associates with several complexes involved in immune responses and acts as a regulatory factor in innate immunity. Through ubiquitination TRIM30 influences signaling pathways and cellular responses to external stimuli maintaining cellular homeostasis.

Pathways

TRIM30 influences signal transduction by interacting with important molecules in pathways like the NF-kB signaling and MAPK pathways. In the NF-kB signaling pathway TRIM30 can modulate the activation of NF-kB impacting the expression of pro-inflammatory cytokines and immune responses. Within the MAPK pathway this modulation affects cellular responses like proliferation and apoptosis. TRIM30 thereby interacts with other proteins such as TAB2 and TAK1 shaping the downstream consequences of these pathways.