AB68071

Anti-TRIM22抗体

Name: TRIM22抗体 (ab68071)| Abcam中文官网
Brand: Abcam Limited
SKU: AB68071
Price: 4744 CNY
Availability: InStock

Anti-TRIM22 antibody

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(7 Publications)

Mouse Polyclonal TRIM22 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TRIM22.

查看别名

RNF94, STAF50, TRIM22, E3 ubiquitin-protein ligase TRIM22, 50 kDa-stimulated trans-acting factor, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, Staf-50, Tripartite motif-containing protein 22

1 Images

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Western blot - Anti-TRIM22 antibody (AB68071)

All lanes:

Western blot - Anti-TRIM22 antibody (ab68071) at 1/500 dilution

Lane 1:

Trim22 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 57 kDa

Observed band size: 60 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

applications

免疫原

Recombinant Full Length Protein corresponding to Human TRIM22.

Q8IYM9

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

pH: 7.4 Constituents: PBS

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRIM22 also known as Staf50 is a protein encoded by the TRIM22 gene. It weighs approximately 56 kDa. TRIM22 is expressed in different tissues throughout the body including the spleen thymus and liver. This protein belongs to the tripartite motif (TRIM) family which is characterized by a distinct structure comprising a RING finger B-box domains and a coiled-coil region. The presence of a RING finger domain suggests that TRIM22 might have E3 ubiquitin ligase activity.

Biological function summary

TRIM22 plays a significant role in innate immunity influencing the antiviral response. As an E3 ubiquitin ligase it facilitates the ubiquitination and degradation of host proteins that are involved in viral replication processes. TRIM22 does not generally function in a protein complex but it interacts with other proteins in a cellular context. This interaction enhances the cellular response against viral infections by disrupting viral components and inhibiting viral replication.

Pathways

TRIM22 is involved in the IFN (interferon) signaling pathway which is essential for the immune response against pathogens. In this pathway TRIM22 interacts with proteins like IFNAR1 and STAT1 acting as a mediator of antiviral activities. It also participates in the ubiquitin-proteasome system aiding in the regulation of protein turnover within the cell. These pathways demonstrate the broad scope of TRIM22 in maintaining cellular homeostasis and responding to external immune challenges.

TRIM22 has been linked to conditions such as systemic lupus erythematosus (SLE) and certain cancers. In SLE TRIM22 expression is often dysregulated contributing to an altered immune response. The protein also connects with STAT proteins which can be influential in autoimmune disease pathways. Moreover aberrant expression of TRIM22 has been observed in some cancer types suggesting a role in tumor biology and potentially offering a target for therapeutic intervention.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

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Visit the Troubleshooting

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靶点信息

Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity (PubMed : 25683609, PubMed : 35777501). Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) (PubMed : 25683609, PubMed : 35777501, PubMed : 36042495). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A (PubMed : 25683609). Acts also by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation (PubMed : 36042495). Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter (PubMed : 26683615). Plays also a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI (PubMed : 36159777). Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction (PubMed : 35777501).

See full target information TRIM22

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Redox report : communications in free radical research 29:2404794 PubMed39314036

2024

WTAP-mediated mA modification of TRIM22 promotes diabetic nephropathy by inducing mitochondrial dysfunction via ubiquitination of OPA1.

Applications

Unspecified application

Species

Unspecified reactive species

Zeng Zhang,Fengzhu Zhou,Min Lu,Duanchun Zhang,Xinyi Zhang,Siyu Xu,Yanming He

Brain and behavior 14:e3465 PubMed38468469

2024

SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Li,Guangzhao Li,Longyuan Li,Bixi Gao,Xiaowang Niu,Yunjiang Wang,Zhong Wang

Molecular medicine reports 26: PubMed35946462

2022

FOXC1‑mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast‑like synoviocytes in rheumatoid arthritis via NF‑κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yazhi Wei,Xinmin Huang,Yanmei Ma,Liping Dai

Molecular medicine reports 26: PubMed35674157

2022

Role of TRIM22 in ulcerative colitis and its underlying mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Ye,Zhongkai Lu

Journal of virology 96:e0159721 PubMed34757838

2021

MicroRNA-376b-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Restriction Factor TRIM22.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Chen,Shijie Zhao,Zhiying Cui,Wen Li,Pengli Xu,Huimin Liu,Xinyong Miao,Yu Chen,Fangfang Han,Hongying Zhang,Pingan Xia,Yina Zhang

Bioengineered 12:7213-7222 PubMed34558381

2021

Knockdown of Tripartite motif-containing 22 (TRIM22)relieved the apoptosis of lens epithelial cells by suppressing the expression of TNF receptor-associated factor 6 (TRAF6).

Applications

Unspecified application

Species

Unspecified reactive species

Kai Meng,Chengbo Fang

BMC biology 15:9 PubMed28193224

2017

MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging.

Applications

Unspecified application

Species

Unspecified reactive species

Roberto Ripa,Luca Dolfi,Marco Terrigno,Luca Pandolfini,Aurora Savino,Valeria Arcucci,Marco Groth,Eva Terzibasi Tozzini,Mario Baumgart,Alessandro Cellerino

View all publications

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Anti-TRIM22抗体

Anti-TRIM22 antibody

Western blot - Anti-TRIM22 antibody (AB68071)