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AB72179

Anti-TRH-R抗体

Anti-TRH-R antibody

4

(2 Reviews)

|

(5 Publications)

Rabbit Polyclonal TRH-R antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Thyrotropin-releasing hormone receptor aa 350 to C-terminus.

查看别名

Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor, TRHR

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRH-R antibody (AB72179)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TRH-R antibody (AB72179)

ab72179 at 10μg/ml staining TRH-R in human thyroid by Immunohistochemistry using paraffin-embedded tissue.

Western blot - Anti-TRH-R antibody (AB72179)
  • WB

Unknown

Western blot - Anti-TRH-R antibody (AB72179)

All lanes:

Western blot - Anti-TRH-R antibody (ab72179) at 0.5 µg/mL

Lane 1:

Human brain lysate

Lane 2:

Human brain lysate with immunising peptide

Predicted band size: 45 kDa

Observed band size: 45 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human Thyrotropin-releasing hormone receptor aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P34981

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
存储溶液
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.2% Gelatin
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

TRH-R also known as Thyrotropin-Releasing Hormone Receptor is a G-protein-coupled receptor specifically binding the tripeptide hormone TRH. This receptor has a molecular weight of approximately 70 kDa. It is express in high levels in the anterior pituitary gland as well as the central nervous system and various peripheral tissues. TRH-R plays a mechanical role in mediating the effects of TRH which include stimulating the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary.
Biological function summary

The TRH-R is involved in important physiological processes. The binding of TRH to TRH-R initiates a cascade of intracellular events leading to the activation of phospholipase C and the subsequent production of inositol triphosphate and diacylglycerol. This signaling pathway elevates intracellular calcium levels and ultimately modulates the secretion of hormones like TSH. TRH-R does not form part of a larger complex but relies on interaction with heterotrimeric G proteins to exert its effects.

Pathways

TRH-R is significantly involved in the hypothalamic-pituitary-thyroid axis. Upon activation by TRH TRH-R activates signaling pathways that regulate thyroid hormone levels playing a role in metabolism. It also interacts with other receptors such as somatostatin receptors which can modulate the inhibitory effects on hormone secretion processes.

The dysregulation of TRH-R function has links with conditions like hypothyroidism and hyperprolactinemia. In these disorders the altered signaling of TRH-R influences the levels of important hormones such as TSH and prolactin. TRH-R connects with thyrotropin and prolactin-related proteins which serves as both diagnostic markers and potential therapeutic targets in these diseases.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
See full target information Thyrotropin-releasing hormone receptor
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37686439

2023

Novel Correlation between TGF-β1/-β3 and Hormone Receptors in the Human Corneal Stroma.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander J Choi,Brenna S Hefley,Sarah E Nicholas,Rebecca L Cunningham,Dimitrios Karamichos

International journal of molecular sciences 21: PubMed32093298

2020

Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures.

Applications

Unspecified application

Species

Unspecified reactive species

Santiago Pech-Pool,Laura C Berumen,Carlos G Martínez-Moreno,Guadalupe García-Alcocer,Martha Carranza,Maricela Luna,Carlos Arámburo

The veterinary quarterly 38:72-78 PubMed30362899

2018

TRH-induced secretion of adrenocorticotropin and cortisol in dogs with pituitary-dependent hypercortisolism.

Applications

Unspecified application

Species

Unspecified reactive species

Tera Pijnacker,Marieke Knies,Sara Galac,Karin Sanders,Jan A Mol,Hans S Kooistra

Neuropeptides 70:47-54 PubMed29803395

2018

The potential role of thyrotropin-releasing hormone in colonic dysmotility induced by water avoidance stress in rats.

Applications

WB, IHC-P

Species

Unspecified reactive species, Unspecified reactive species

Yanzhen Zhang,Chunfeng Wang,Lianfeng Zhang

The Journal of physiology 593:415-30 PubMed25630262

2015

RNASeq-derived transcriptome comparisons reveal neuromodulatory deficiency in the CO₂ insensitive brown Norway rat.

Applications

Unspecified application

Species

Unspecified reactive species

Madeleine M Puissant,Ashley E Echert,Chun Yang,Gary C Mouradian,Tyler Novotny,Pengyuan Liu,Mingyu Liang,Matthew R Hodges
View all publications
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