Anti-TREM2抗体[6E9] (ab125117)
![Flow Cytometry - Anti-TREM2 antibody [6E9] (ab125117)](https://www.abcam.cn/ps/products/125/ab125117/Images/ab125117-454450-anti-trem2-antibody-6e9-flow-cyt-raw-cells.JPG "Flow Cytometry - Anti-TREM2 antibody [6E9] (ab125117)")
Key features and details
- Rat monoclonal [6E9] to TREM2
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2b
Related conjugates and formulations
概述
-
产品名称
Anti-TREM2抗体[6E9]
参阅全部 TREM2 一抗 -
描述
大鼠单克隆抗体[6E9] to TREM2 -
宿主
Rat -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Mouse recombinant TREM2 protein.
-
阳性对照
- Flow Cyt: Mouse RAW cells.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.02% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
6E9 -
同种型
IgG2b -
研究领域
相关产品
-
Alternative Versions
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab125117于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
1/50.
|
| 说明 |
|---|
|
Flow Cyt
1/50. |
靶标
-
功能
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. -
组织特异性
Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord. -
疾病相关
Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. -
序列相似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 83433 Mouse
- SwissProt: Q99NH8 Mouse
- Unigene: 261623 Mouse
-
别名
- TREM 2 antibody
- TREM-2 antibody
- TREM2 antibody
see all
图片
-
Flow Cytometry - Anti-TREM2 antibody [6E9] (ab125117)
Flow cytometry of Mouse RAW cells labelling TREM2 with ab125117 at 1 µg/250,000 cells. The black line represents cell only and the red line represents the isotype control.
实验方案
数据表及文件
-
Datasheet download
文献 (3)
ab125117 被引用在 3 文献中.
- Xue T et al. Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury. Acta Pharm Sin B 12:1885-1898 (2022). PubMed: 35847502
- Li Y et al. TREM2 Regulates High Glucose-Induced Microglial Inflammation via the NLRP3 Signaling Pathway. Brain Sci 11:N/A (2021). PubMed: 34356130
- Qu W et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol 9:1121 (2018). PubMed: 29887864
