Anti-TRAP/CD40L抗体[AP-MAB0820] (ab83050)
Key features and details
- Armenian hamster monoclonal [AP-MAB0820] to TRAP/CD40L
- Suitable for: IHC-Fr, Inhibition Assay, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG
概述
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产品名称
Anti-TRAP/CD40L抗体[AP-MAB0820]
参阅全部 TRAP/CD40L 一抗 -
描述
亚美尼亚仓鼠单克隆抗体[AP-MAB0820] to TRAP/CD40L -
宿主
Armenian hamster -
经测试应用
适用于: IHC-Fr, Inhibition Assay, Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse TRAP/CD40L. Activated Mouse Th1 cells.
Database link: P27548 -
常规说明
This monoclonal is azide-free & contains an extremely low level of LPS (< 0.002EU/µg IgG).This hamster monoclonal may be used to inhibit the activation of T and B lymphocytes in vitro and to study antigen-specific lymphocyte responses in vivo.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading... -
纯化说明
The IgG fraction of culture supernatant was purified by Protein A/Gaffinity chromatography. -
Primary antibody说明
This hamster monoclonal may be used to inhibit the activation of T and B lymphocytes in vitro and to study antigen-specific lymphocyte responses in vivo. -
克隆
单克隆 -
克隆编号
AP-MAB0820 -
同种型
IgG -
研究领域
相关产品
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab83050于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
|
| Inhibition Assay |
Use at an assay dependent concentration.
|
|
| Flow Cyt |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
Inhibition Assay
Use at an assay dependent concentration. |
|
Flow Cyt
Use at an assay dependent concentration. |
靶标
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功能
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. -
组织特异性
Specifically expressed on activated CD4+ T-lymphocytes. -
疾病相关
Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. -
序列相似性
Belongs to the tumor necrosis factor family. -
翻译后修饰
The soluble form derives from the membrane form by proteolytic processing.
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
Not O-glycosylated. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 21947 Mouse
- SwissProt: P27548 Mouse
- Unigene: 4861 Mouse
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别名
- CD 40L antibody
- CD154 antibody
- CD40 antigen ligand antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (0)
ab83050 尚未被引用在任何文献中。
