Anti-Transglutaminase 5/TGM5抗体(ab133786)
Key features and details
- Rabbit polyclonal to Transglutaminase 5/TGM5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-Transglutaminase 5/TGM5抗体
参阅全部 Transglutaminase 5/TGM5 一抗 -
描述
兔多克隆抗体to Transglutaminase 5/TGM5 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human Transglutaminase 5/TGM5 (C terminal).
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阳性对照
- Human spleen and liver tissues
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
存储溶液
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab133786于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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说明 |
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IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes. -
组织特异性
Expressed in foreskin keratinocytes. -
疾病相关
Defects in TGM5 are a cause of peeling skin syndrome type A (APSS) [MIM:609796]. A non-inflammatory form of peeling skin syndrome, a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis. In APSS patients, skin peeling is strictly limited to the dorsa of the hands and feet, and it is accompanied by accompanied by painless erythema and spontaneous non-scarring healing. Ultrastructural and histological analysis shows a level of blistering high in the epidermis at the stratum granulosum-stratum corneum junction. -
序列相似性
Belongs to the transglutaminase superfamily. Transglutaminase family. -
细胞定位
Cytoplasm. Associated with intermediate filaments. - Information by UniProt
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数据库链接
- Entrez Gene: 9333 Human
- Entrez Gene: 74176 Mouse
- Entrez Gene: 691929 Rat
- Omim: 603805 Human
- SwissProt: O43548 Human
- SwissProt: Q3V1F9 Mouse
- SwissProt: Q9D7I9 Mouse
- Unigene: 129719 Human
see all -
别名
- Protein glutamine gamma glutamyltransferase 5 antibody
- Protein-glutamine gamma-glutamyltransferase 5 antibody
- PSS2 antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transglutaminase 5/TGM5 antibody (ab133786)
Immunohistochemical analysis of formalin fixed, paraffin-embedded Human spleen tissue labelling Transglutaminase 5/TGM5 with ab133786 at 5 µg/ml. Primary antibody labelling was followed by a biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transglutaminase 5/TGM5 antibody (ab133786)
Immunohistochemical analysis of formalin fixed, paraffin-embedded Human liver tissue labelling Transglutaminase 5/TGM5 with ab133786 at 5 µg/ml. Primary antibody labelling was followed by a biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
数据表及文件
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Datasheet download
文献 (3)
ab133786 被引用在 3 文献中.
- Somogyi O et al. New Data on the Features of Skin Barrier in Hidradenitis Suppurativa. Biomedicines 11:N/A (2023). PubMed: 36672635
- Kapitány A et al. Regional Differences in the Permeability Barrier of the Skin-Implications in Acantholytic Skin Diseases. Int J Mol Sci 22:N/A (2021). PubMed: 34638769
- Medgyesi B et al. Rosacea Is Characterized by a Profoundly Diminished Skin Barrier. J Invest Dermatol 140:1938-1950.e5 (2020). PubMed: 32199994