Anti-TRAIL抗体(ab2056)
Key features and details
- Rabbit polyclonal to TRAIL
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TRAIL抗体
参阅全部 TRAIL 一抗 -
描述
兔多克隆抗体to TRAIL -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human TRAIL aa 261-277 (C terminal).
Sequence:CTNEHLIDMDHEASFFGA
(Peptide available asab7867) -
阳性对照
- HeLa whole cell lysate.
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常规说明
Ligand for DR4 and DR5.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide -
Concentration information loading...
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纯度
Affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
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Recombinant Protein
应用
应用 | Ab评论 | 说明 |
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IHC-P |
Use a concentration of 20 µg/ml.
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WB |
1/500. Detects a band of approximately 32 kDa.Can be blocked with TRAIL peptide (ab7867).
Gives a 32 kD band which represents the membrane-bound form of TRAIL. |
说明 |
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IHC-P
Use a concentration of 20 µg/ml. |
WB
1/500. Detects a band of approximately 32 kDa.Can be blocked with TRAIL peptide (ab7867). Gives a 32 kD band which represents the membrane-bound form of TRAIL. |
靶标
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功能
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. -
组织特异性
Widespread; most predominant in spleen, lung and prostate. -
序列相似性
Belongs to the tumor necrosis factor family. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 8743 Human
- Omim: 603598 Human
- SwissProt: P50591 Human
- Unigene: 478275 Human
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别名
- Apo 2 ligand antibody
- APO 2L antibody
- Apo-2 ligand antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human brain tissue staining TRAIL with ab2056 at 20µg/ml
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Western Blot of human brain lysate labeling TRAIL with Anti-TRAIL antibody (ab2056) at (1) 2.5 and (2) 5 µg/ml.
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Western blot analysis of HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein including extracellular domain of TRAIL with anti-TRAIL at 1 µg/ml Western blot analysis of HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of TRAIL with anti-TRAIL at 1 µg/ml.
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Immunohistochemistry of TRAIL in human brain tissue with TRAIL antibody at 20 µg/ml.
数据表及文件
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Datasheet download
文献 (4)
ab2056 被引用在 4 文献中.
- Vetsika EK et al. Small Extracellular Vesicles in Pre-Therapy Plasma Predict Clinical Outcome in Non-Small-Cell Lung Cancer Patients. Cancers (Basel) 13:N/A (2021). PubMed: 33922569
- Melendez ME et al. Construction and characterization of a new TRAIL soluble form, active at picomolar concentrations. Oncotarget 9:27233-27241 (2018). PubMed: 29930761
- Ludwig S et al. Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer. Clin Cancer Res 23:4843-4854 (2017). PubMed: 28400428
- Kawano Y et al. TRAIL produced from multiple myeloma cells is associated with osteolytic markers. Oncol Rep 27:39-44 (2012). PubMed: 21993926