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重组RabMAb

重组Anti-TR4抗体[EPR1772(2)] (ab109513)

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Western blot - Anti-TR4 antibody [EPR1772(2)] (ab109513)
  • Anti-TR4 antibody [EPR1772(2)] (ab109513)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR1772(2)] to TR4
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

概述

  • 产品名称

    Anti-TR4抗体[EPR1772(2)]
    参阅全部 TR4 一抗

  • 描述

    兔单克隆抗体[EPR1772(2)] to TR4

  • 宿主

    Rabbit

  • 经测试应用

    适用于: WBmore details
    不适用于: Flow Cyt,ICC/IF or IHC-P

  • 种属反应性

    与反应: Human

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • 阳性对照

    • 293T, PC-3 and U937 cell lysates

  • 常规说明

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

The Abpromise guarantee

Abpromise™承诺保证使用ab109513于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

应用 Ab评论 说明
WB
1/1000 - 1/10000. Detects a band of approximately 67 kDa (predicted molecular weight: 65 kDa).
说明
WB
1/1000 - 1/10000. Detects a band of approximately 67 kDa (predicted molecular weight: 65 kDa).
应用说明
Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

靶标

  • 功能

    Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

  • 序列相似性

    Belongs to the nuclear hormone receptor family. NR2 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.

  • 发展阶段

    Transiently repressed during the meiotic phase of spermatogenesis.

  • 翻译后修饰

    Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the nonphosphorylated form preferentially recruits the coactivator, PCAF.

  • 细胞定位

    Nucleus.
  • Information by UniProt

  • 数据库链接

    • 形式

      There are 2 isoforms produced by alternative splicing.

    • 别名

      • hTAK1 antibody
      • Nr2c2 antibody
      • NR2C2_HUMAN antibody
      • Nuclear hormone receptor TR4 antibody
      • Nuclear receptor subfamily 2 group C member 2 antibody
      • Orphan nuclear receptor TAK1 antibody
      • Orphan nuclear receptor TR4 antibody
      • TAK1 antibody
      • Testicular nuclear receptor 4 antibody
      • Testicular receptor 4 antibody
      • TR2R1 antibody
      • TR4 antibody
      • TR4 nuclear hormone receptor antibody
      see all

    图片

    • Western blot - Anti-TR4 antibody [EPR1772(2)] (ab109513)
      Western blot - Anti-TR4 antibody [EPR1772(2)] (ab109513)
      All lanes : Anti-TR4 antibody [EPR1772(2)] (ab109513) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : PC-3 cell lysate
      Lane 3 : U937 lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 65 kDa
      Observed band size: 67 kDa why is the actual band size different from the predicted?

    • Anti-TR4 antibody [EPR1772(2)] (ab109513)
      Anti-TR4 antibody [EPR1772(2)] (ab109513)

    文献 (1)

    发表研究结果有使用 ab109513？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab109513 被引用在 1 文献中.

    • Zhu J  et al. Use of miR-145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer. Oncol Rep 45:963-974 (2021). PubMed: 33650661

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