重组Anti-TPOR/MPL抗体[S03-1C9] (ab317404)
![Western blot - Anti-TPOR/MPL Antibody [S03-1C9] (ab317404)](https://www.abcam.cn/ps/products/317/ab317404/Images/ab317404-1-anti-tpor-mpl-antibody-s03-1c9-western-blot-k562-3t3-human-mouse.jpg "Western blot - Anti-TPOR/MPL Antibody [S03-1C9] (ab317404)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [S03-1C9] to TPOR/MPL
- Suitable for: WB
- Reacts with: Mouse, Human
概述
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产品名称
Anti-TPOR/MPL抗体[S03-1C9]
参阅全部 TPOR/MPL 一抗 -
描述
兔单克隆抗体[S03-1C9] to TPOR/MPL -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human TPOR/MPL.
Database link: P40238 -
阳性对照
- WB: K562 and NIH/3T3 cell lysate.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.4
Preservative: 0.01% Sodium azide
Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA -
Concentration information loading... -
纯度
Affinity purified -
克隆
单克隆 -
克隆编号
S03-1C9 -
同种型
IgG -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab317404于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB |
1/1000 - 1/5000. Predicted molecular weight: 71 kDa.
|
| 说明 |
|---|
|
WB
1/1000 - 1/5000. Predicted molecular weight: 71 kDa. |
靶标
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功能
Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. -
组织特异性
Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. -
疾病相关
Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. -
序列相似性
Belongs to the type I cytokine receptor family. Type 1 subfamily.
Contains 2 fibronectin type-III domains. -
结构域
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
细胞定位
Membrane. - Information by UniProt
-
数据库链接
- Entrez Gene: 4352 Human
- Entrez Gene: 17480 Mouse
- Omim: 159530 Human
- SwissProt: P40238 Human
- SwissProt: Q08351 Mouse
- Unigene: 82906 Human
- Unigene: 4864 Mouse
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别名
- C MPL antibody
- CD110 antibody
- mpl antibody
see all
图片
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Western blot - Anti-TPOR/MPL Antibody [S03-1C9] (ab317404)All lanes : Anti-TPOR/MPL Antibody [S03-1C9] (ab317404) at 1/1000 dilution
Lane 1 : K562 cell lysate
Lane 2 : NIH/3T3 cell lysate
Predicted band size: 71 kDa
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab317404 尚未被引用在任何文献中。