Anti-TNF Receptor II抗体[HM102] (ab7369)
Key features and details
- Rat monoclonal [HM102] to TNF Receptor II
- Suitable for: IHC-Fr, IP, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2a
概述
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产品名称
Anti-TNF Receptor II抗体[HM102]
参阅全部 TNF Receptor II 一抗 -
描述
大鼠单克隆抗体[HM102] to TNF Receptor II -
宿主
Rat -
特异性
Mouse TNF-R II and the soluble receptor. -
经测试应用
适用于: IHC-Fr, IP, Flow Cytmore details -
种属反应性
与反应: Mouse -
表位
Extra-cellular part of the receptor. -
常规说明
The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-alpha.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.1% Sodium azide
Constituent: 1% BSA -
Concentration information loading... -
纯度
Protein G purified -
克隆
单克隆 -
克隆编号
HM102 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
|
| IP |
Use at an assay dependent concentration.
|
|
| Flow Cyt |
Use at an assay dependent concentration.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
| 说明 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
|
Flow Cyt
Use at an assay dependent concentration. ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. -
序列相似性
Contains 4 TNFR-Cys repeats. -
翻译后修饰
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. -
细胞定位
Secreted and Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 21938 Mouse
- SwissProt: P25119 Mouse
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别名
- CD120b antibody
- p75 antibody
- p75 TNF receptor antibody
see all
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab7369 被引用在 3 文献中.
- Fu XQ et al. Tumor necrosis factor alpha mediates neuromuscular synapse elimination. Cell Discov 6:9 (2020). PubMed: 32140252
- Fan J et al. Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation. Alcohol Clin Exp Res 35:47-59 (2011). PubMed: 21039629
- Tesz GJ et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 282:19302-12 (2007). Mouse . PubMed: 17500068