Anti-TNF Receptor I抗体(ab19139)
Key features and details
- Rabbit polyclonal to TNF Receptor I
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-TNF Receptor I抗体
参阅全部 TNF Receptor I 一抗 -
描述
兔多克隆抗体to TNF Receptor I -
宿主
Rabbit -
经测试应用
适用于: IHC-P, WBmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Mouse TNF Receptor I aa 1-100.
Database link: P25118 -
阳性对照
- WB: Heat-shocked HeLa cell lysate, Jurkat cell lysate. IHC-P: Human spleen
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.2
Preservative: 0.09% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
纯度
Affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab19139于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | (4) |
Use a concentration of 1 - 10 µg/ml.
|
| WB | (7) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa.
|
| 说明 |
|---|
|
IHC-P
Use a concentration of 1 - 10 µg/ml. |
|
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 50 kDa. |
靶标
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功能
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. -
疾病相关
Familial hibernian fever
Multiple sclerosis 5 -
序列相似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
结构域
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. -
翻译后修饰
The soluble form is produced from the membrane form by proteolytic processing. -
细胞定位
Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 7132 Human
- Omim: 191190 Human
- SwissProt: P19438 Human
- Unigene: 279594 Human
- Unigene: 713833 Human
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别名
- CD120a antibody
- FPF antibody
- MGC19588 antibody
see all
图片
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Western blot - Anti-TNF Receptor I antibody (ab19139)All lanes : Anti-TNF Receptor I antibody (ab19139) at 1 µg/ml
Lane 1 : Heat-shocked HeLa cell lysate
Lane 2 : Jurkat cell lysate
Predicted band size: 50 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TNF Receptor I antibody (ab19139)Immunohistochemistry Formalin/PFA-fixed paraffin-embedded human spleen sections labeling TNF Receptor I with ab19139 at 10ug/mL.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (121)
ab19139 被引用在 121 文献中.
- Jeon JH et al. Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model. Sci Rep 13:2520 (2023). PubMed: 36781906
- Hsu CL et al. Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy. Int J Mol Sci 24:N/A (2023). PubMed: 36675019
- Henning L et al. Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy. Glia 71:168-186 (2023). PubMed: 36373840
- Li H et al. TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma. Chin J Cancer Res 35:66-80 (2023). PubMed: 36910852
- Boehm E et al. Cannabidiol attenuates inflammatory impairment of intestinal cells expanding biomaterial-based therapeutic approaches. Mater Today Bio 23:100808 (2023). PubMed: 37779918