Anti-TNF Receptor I抗体[55R-170] (ab106099)
Key features and details
- Armenian Hamster monoclonal [55R-170] to TNF Receptor I
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
概述
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产品名称
Anti-TNF Receptor I抗体[55R-170]
参阅全部 TNF Receptor I 一抗 -
描述
亚美尼亚仓鼠单克隆抗体[55R-170] to TNF Receptor I -
宿主
Armenian hamster -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Purified extracellular domain of Mouse Soluble TNF Receptor I.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituents: 0.1% BSA, PBS -
Concentration information loading... -
纯度
Protein G purified -
纯化说明
ab106099 is 0.2 µm filtered. -
克隆
单克隆 -
克隆编号
55R-170 -
同种型
IgG1 -
研究领域
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106099于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
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| 说明 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. |
靶标
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功能
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. -
疾病相关
Familial hibernian fever
Multiple sclerosis 5 -
序列相似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
结构域
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. -
翻译后修饰
The soluble form is produced from the membrane form by proteolytic processing. -
细胞定位
Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 21937 Mouse
- SwissProt: P25118 Mouse
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别名
- CD120a antibody
- FPF antibody
- MGC19588 antibody
see all
实验方案
数据表及文件
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Datasheet download
文献 (3)
ab106099 被引用在 3 文献中.
- Ding Y et al. Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus. Ann N Y Acad Sci 1490:77-89 (2021). PubMed: 33543485
- Akhtar MN et al. Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells. PLoS Pathog 16:e1009136 (2020). PubMed: 33370418
- Sheehan KC et al. Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75. J Exp Med 181:607-17 (1995). PubMed: 7836916
